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A new sensitive, specific, and rapid radioimmunoassay procedure for the determination of plasma concentrations of the antiemetic drug prochlorperazine is described. The assay enables the quantitation of 31 pg of the drug in 200 microliters of plasma with a coefficient of variation of approximately 2%. Except for N-desmethylprochlorperazine, the antiserum did not cross-react with the available metabolites tested. Also there was no cross-reactivity with the tricyclic antidepressants and antianxiety agents commonly co-administered with the drug. The method is suitable for single-dose pharmacokinetic and bioavailability studies. It should be adequate for the therapeutic monitoring of the drug in patients.
K K Midha, and
E M Hawes, and
G Rauw, and
J McVittie, and
G McKay, and
J K Cooper, and
H U Shetty
December 1980,
Journal of pharmaceutical sciences,
K K Midha, and
E M Hawes, and
G Rauw, and
J McVittie, and
G McKay, and
J K Cooper, and
H U Shetty
January 1980,
Communications in psychopharmacology,
K K Midha, and
E M Hawes, and
G Rauw, and
J McVittie, and
G McKay, and
J K Cooper, and
H U Shetty
March 1978,
British journal of clinical pharmacology,
K K Midha, and
E M Hawes, and
G Rauw, and
J McVittie, and
G McKay, and
J K Cooper, and
H U Shetty
January 1981,
British journal of clinical pharmacology,
K K Midha, and
E M Hawes, and
G Rauw, and
J McVittie, and
G McKay, and
J K Cooper, and
H U Shetty
October 1982,
Clinica chimica acta; international journal of clinical chemistry,
K K Midha, and
E M Hawes, and
G Rauw, and
J McVittie, and
G McKay, and
J K Cooper, and
H U Shetty
November 1979,
The Journal of endocrinology,
K K Midha, and
E M Hawes, and
G Rauw, and
J McVittie, and
G McKay, and
J K Cooper, and
H U Shetty
May 1979,
Acta endocrinologica,
K K Midha, and
E M Hawes, and
G Rauw, and
J McVittie, and
G McKay, and
J K Cooper, and
H U Shetty
June 1973,
Biochemical medicine,
K K Midha, and
E M Hawes, and
G Rauw, and
J McVittie, and
G McKay, and
J K Cooper, and
H U Shetty
July 1976,
Clinica chimica acta; international journal of clinical chemistry,
K K Midha, and
E M Hawes, and
G Rauw, and
J McVittie, and
G McKay, and
J K Cooper, and
H U Shetty
December 1976,
Endocrinologia japonica,
