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A good model of the adult respiratory distress syndrome (ARDS) is intravenously injected phorbol myristate acetate (PMA), which causes pulmonary sequestration of neutrophils and a neutrophil-dependent acute edematous lung injury in rabbits. In the present study, pretreatment of rabbits with the antimalarial agent, mepacrine, prevented lung edema after injection of PMA without altering initial accumulations of neutrophils in the lung. Mepacrine also decreased oxygen radical production and degranulation by neutrophils stimulated by PMA in vitro. In contrast, pretreatment with methylprednisolone did not decrease edematous lung injury in rabbits given PMA nor did it inhibit O2 radical production or degranulation by neutrophils treated with PMA in vitro. Our results suggest that agents that modify neutrophil function may be useful in decreasing lung injury after PMA treatment and, perhaps, in treating patients with ARDS.
E M Canham, and
S A Shoemaker, and
R M Tate, and
R N Harada, and
I F McMurtry, and
J E Repine
July 1986,
Journal of applied physiology (Bethesda, Md. : 1985),
E M Canham, and
S A Shoemaker, and
R M Tate, and
R N Harada, and
I F McMurtry, and
J E Repine
April 1982,
The American journal of pathology,
E M Canham, and
S A Shoemaker, and
R M Tate, and
R N Harada, and
I F McMurtry, and
J E Repine
April 1982,
The American review of respiratory disease,
E M Canham, and
S A Shoemaker, and
R M Tate, and
R N Harada, and
I F McMurtry, and
J E Repine
January 1990,
The Chinese journal of physiology,
E M Canham, and
S A Shoemaker, and
R M Tate, and
R N Harada, and
I F McMurtry, and
J E Repine
January 2005,
Pulmonary pharmacology & therapeutics,
E M Canham, and
S A Shoemaker, and
R M Tate, and
R N Harada, and
I F McMurtry, and
J E Repine
December 1988,
The American review of respiratory disease,
E M Canham, and
S A Shoemaker, and
R M Tate, and
R N Harada, and
I F McMurtry, and
J E Repine
June 1992,
Critical care medicine,
E M Canham, and
S A Shoemaker, and
R M Tate, and
R N Harada, and
I F McMurtry, and
J E Repine
August 2004,
Clinical and experimental pharmacology & physiology,
E M Canham, and
S A Shoemaker, and
R M Tate, and
R N Harada, and
I F McMurtry, and
J E Repine
January 1985,
Laboratory investigation; a journal of technical methods and pathology,
E M Canham, and
S A Shoemaker, and
R M Tate, and
R N Harada, and
I F McMurtry, and
J E Repine
January 1995,
Journal of drug targeting,
