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In this study mean 4 p.m. cortisol levels were significantly higher in patients with major depression than in control subjects or in patients with bipolar depression or dysthymic-related disorders. Moreover, the distribution of values differed significantly among groups. Eighteen of 45 patients with major depression had cortisol levels of 10 micrograms/dl or more, compared with 2 of 20 bipolar depressed patients and 0 of 31 controls. Patients with very high cortisol levels (15 micrograms/dl or more) tended to fulfill criteria for major depression with mood-congruent psychosis. The distribution of values in the major depression group also suggested the existence of three major subgroups. The authors discuss the implications of these data.
A F Schatzberg, and
A J Rothschild, and
J B Stahl, and
T C Bond, and
A H Rosenbaum, and
S B Lofgren, and
R A MacLaughlin, and
M A Sullivan, and
J O Cole
January 1985,
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A F Schatzberg, and
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J B Stahl, and
T C Bond, and
A H Rosenbaum, and
S B Lofgren, and
R A MacLaughlin, and
M A Sullivan, and
J O Cole
January 1986,
Actas luso-espanolas de neurologia, psiquiatria y ciencias afines,
A F Schatzberg, and
A J Rothschild, and
J B Stahl, and
T C Bond, and
A H Rosenbaum, and
S B Lofgren, and
R A MacLaughlin, and
M A Sullivan, and
J O Cole
March 1982,
Journal of affective disorders,
A F Schatzberg, and
A J Rothschild, and
J B Stahl, and
T C Bond, and
A H Rosenbaum, and
S B Lofgren, and
R A MacLaughlin, and
M A Sullivan, and
J O Cole
January 1981,
Psychopharmacology bulletin,
A F Schatzberg, and
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J B Stahl, and
T C Bond, and
A H Rosenbaum, and
S B Lofgren, and
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M A Sullivan, and
J O Cole
January 1982,
Biological psychiatry,
A F Schatzberg, and
A J Rothschild, and
J B Stahl, and
T C Bond, and
A H Rosenbaum, and
S B Lofgren, and
R A MacLaughlin, and
M A Sullivan, and
J O Cole
April 1980,
Lancet (London, England),
A F Schatzberg, and
A J Rothschild, and
J B Stahl, and
T C Bond, and
A H Rosenbaum, and
S B Lofgren, and
R A MacLaughlin, and
M A Sullivan, and
J O Cole
January 1985,
Journal of affective disorders,
A F Schatzberg, and
A J Rothschild, and
J B Stahl, and
T C Bond, and
A H Rosenbaum, and
S B Lofgren, and
R A MacLaughlin, and
M A Sullivan, and
J O Cole
August 1983,
Journal of the American Geriatrics Society,
A F Schatzberg, and
A J Rothschild, and
J B Stahl, and
T C Bond, and
A H Rosenbaum, and
S B Lofgren, and
R A MacLaughlin, and
M A Sullivan, and
J O Cole
March 1983,
Clinical neuropharmacology,
A F Schatzberg, and
A J Rothschild, and
J B Stahl, and
T C Bond, and
A H Rosenbaum, and
S B Lofgren, and
R A MacLaughlin, and
M A Sullivan, and
J O Cole
October 1984,
Pennsylvania medicine,
