-transparent.png){kind=logo}
A 60-mo longitudinal study has been undertaken in 99 HBeAg-positive patients with clinicopathologically verified chronic hepatitis. Hepatitis B e antigen clearance occurred in 30 patients at a rate of approximately 17% per year. A phenomenon of abrupt elevation of serum glutamic pyruvic transaminase (greater than 300 IU/L) with histological changes compatible with chronic lobular hepatitis was observed in 13 of 20 patients (65%) preceding spontaneous HBeAg clearance. In contrast, 8 of 10 patients on immunosuppressive or antiviral therapy, or both, had uneventful HBeAg clearance. It was concluded that HBeAg clearance can occur in patients with varying immunologic status. The mechanism responsible for HBeAg clearance awaits further study.
Y F Liaw, and
C M Chu, and
I J Su, and
M J Huang, and
D Y Lin, and
C S Chang-Chien
November 1981,
Annals of internal medicine,
Y F Liaw, and
C M Chu, and
I J Su, and
M J Huang, and
D Y Lin, and
C S Chang-Chien
February 1999,
Hepatology (Baltimore, Md.),
Y F Liaw, and
C M Chu, and
I J Su, and
M J Huang, and
D Y Lin, and
C S Chang-Chien
June 1981,
Annals of internal medicine,
Y F Liaw, and
C M Chu, and
I J Su, and
M J Huang, and
D Y Lin, and
C S Chang-Chien
September 2003,
Chinese medical journal,
Y F Liaw, and
C M Chu, and
I J Su, and
M J Huang, and
D Y Lin, and
C S Chang-Chien
January 2010,
Scandinavian journal of gastroenterology,
Y F Liaw, and
C M Chu, and
I J Su, and
M J Huang, and
D Y Lin, and
C S Chang-Chien
October 2010,
Digestive diseases and sciences,
Y F Liaw, and
C M Chu, and
I J Su, and
M J Huang, and
D Y Lin, and
C S Chang-Chien
January 2018,
Liver international : official journal of the International Association for the Study of the Liver,
Y F Liaw, and
C M Chu, and
I J Su, and
M J Huang, and
D Y Lin, and
C S Chang-Chien
October 1997,
The Journal of infectious diseases,
Y F Liaw, and
C M Chu, and
I J Su, and
M J Huang, and
D Y Lin, and
C S Chang-Chien
August 1980,
Gastroenterology,
Y F Liaw, and
C M Chu, and
I J Su, and
M J Huang, and
D Y Lin, and
C S Chang-Chien
October 2021,
World journal of gastroenterology,
