BIOMAT Database Logo BIOMAT Database Logo

[Inhibition of the process of sugar transport stimulation in the frog sartorius muscles by amines and amides]. 1978

N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin

In the experiments on isolated frog sartorius muscles, amines and amides were found to inhibit the process of stimulation of D-xylose transport induced by insulin, 2,4-dinitrophenol or potassium contracture. The inhibitory action was produced by urea, acetamide, guanidine, NH4Cl, mono-, di- and trimethyl- or ethylamines, some diamines (all the substances being, applied in the concentration range equal to 100 mM). The similar effect was obtained when cystamine (20 mM), tryptamine, 5-methoxytryptamine (2 mM) and adenine, adenosine, guanosine (1-10 mM) were used. There was no inhibitory effect of acetone, glycerol, tetraethylammonium, propilamine, butylamine, aminoacids, spermine, spermidine, ATP, AMP or cAMP. It has been suggested that the inhibitory substances may interact by producing hydrogen bonds from NH-groups with the neutrally or negatively charged groups at the external surface of the muscle membrane in the region with a slow hydrophobicity. As a result, no structural changes required for activation of the sugar transport system occur in the membrane.

UI MeSH Term Description Entries
D007329 Insulin Antagonists Compounds which inhibit or antagonize the biosynthesis or action of insulin. Antagonists, Insulin
D009132 Muscles Contractile tissue that produces movement in animals. Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D011188 Potassium An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
D002463 Cell Membrane Permeability A quality of cell membranes which permits the passage of solvents and solutes into and out of cells. Permeability, Cell Membrane
D004140 Dinitrophenols Organic compounds that contain two nitro groups attached to a phenol.
D000577 Amides Organic compounds containing the -CO-NH2 radical. Amides are derived from acids by replacement of -OH by -NH2 or from ammonia by the replacement of H by an acyl group. (From Grant & Hackh's Chemical Dictionary, 5th ed) Amide
D000588 Amines A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed) Amine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001001 Anura An order of the class Amphibia, which includes several families of frogs and toads. They are characterized by well developed hind limbs adapted for jumping, fused head and trunk and webbed toes. The term "toad" is ambiguous and is properly applied only to the family Bufonidae. Bombina,Frogs and Toads,Salientia,Toad, Fire-Bellied,Toads and Frogs,Anuras,Fire-Bellied Toad,Fire-Bellied Toads,Salientias,Toad, Fire Bellied,Toads, Fire-Bellied
D001692 Biological Transport The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments. Transport, Biological,Biologic Transport,Transport, Biologic

Related Publications

N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin
[Kinetic parameters of sugar transport in frog sartorius muscles].
March 1973, Tsitologiia,
N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin
[Stimulation of sugar transport in frog sartorius muscles induced by increased potassium concentration in the medium].
July 1971, Tsitologiia,
N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin
[Effect of insulin on sugar transport in the frog sartorius muscles].
January 1973, Problemy endokrinologii,
N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin
Specificity of the effect of insulin on permeability of frog sartorius muscles to sugar.
January 1967, Diabetes,
N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin
[Heat shortening of frog sartorius muscles].
September 1971, Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin
Action of insulin on the transport of 3-O-methylglucose in frog sartorius muscles.
May 1983, The Journal of biological chemistry,
N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin
[Effect of adrenaline on transport rate and utilization of glucose in frog sartorius muscles].
October 1973, Tsitologiia,
N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin
[Duration of the activated state of the sugar transport system in frog skeletal muscles following their stimulation].
December 1971, Tsitologiia,
N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin
On electromechanical behaviour of frog sartorius muscles.
January 2005, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference,
N A Vinogradova, and N N Nikol'skiĭ, and A S Troshin
Radiocalcium release by stimulated and potassium-treated sartorius muscles of the frog.
January 1960, The Journal of general physiology,
Copied contents to your clipboard!