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To isolate transferrin and additional amounts of albumin the parameters are developed for subfractionating with the alcohol-rivanol method fraction IV (according to Cohn) of plasma proteins (waste of albumin production from plasma of donor blood). The suggested method for fraction IV subfractionating makes it possible to obtain true albumin and transferrin. In all series the yield of wet and dry sediments of transferrin is constant. To remove alcohol from albumin and transferrin half-finished products the regimes of sublimation drying are worked out at which protein is not denaturated. Albumin obtained from fraction IV satisfies all the requirements of MPTY-42 N 3500-67 for the albumin preparation from donor blood. The developed method for subfractioning fraction IV of plasma proteins is easily reproduced on an industrial scale, permits a 8% increase in albumin yield from 1 1 of plasma and a simultaneous obtaining of transferrin which may be a basis for medicinal preparation.
K A Lobunets, and
N I Lapicheva, and
I N Fateeva, and
L M Gruzova, and
A A Kirillova
June 1990,
Acta endocrinologica,
K A Lobunets, and
N I Lapicheva, and
I N Fateeva, and
L M Gruzova, and
A A Kirillova
February 1986,
Acta endocrinologica,
K A Lobunets, and
N I Lapicheva, and
I N Fateeva, and
L M Gruzova, and
A A Kirillova
January 1975,
Preparative biochemistry,
K A Lobunets, and
N I Lapicheva, and
I N Fateeva, and
L M Gruzova, and
A A Kirillova
February 1968,
Archives of biochemistry and biophysics,
K A Lobunets, and
N I Lapicheva, and
I N Fateeva, and
L M Gruzova, and
A A Kirillova
January 1998,
Advances in experimental medicine and biology,
K A Lobunets, and
N I Lapicheva, and
I N Fateeva, and
L M Gruzova, and
A A Kirillova
June 1971,
Biochemical and biophysical research communications,
K A Lobunets, and
N I Lapicheva, and
I N Fateeva, and
L M Gruzova, and
A A Kirillova
May 1978,
Biochimica et biophysica acta,
K A Lobunets, and
N I Lapicheva, and
I N Fateeva, and
L M Gruzova, and
A A Kirillova
February 1973,
Immunochemistry,
K A Lobunets, and
N I Lapicheva, and
I N Fateeva, and
L M Gruzova, and
A A Kirillova
January 1976,
Advances in experimental medicine and biology,
K A Lobunets, and
N I Lapicheva, and
I N Fateeva, and
L M Gruzova, and
A A Kirillova
October 1962,
Archives of biochemistry and biophysics,
