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Experiments on male rats have shown that the inhibitory effect of peritol on the hypothalamohypophyseal-adrenal system (HHAS) is determined both by its influence on the regulatory mechanisms of the CNS and direct action on secretion and, possibly, synthesis of steroids. The degree of the antiserotonin and the HHAS-inhibiting effects depends on the frequency of drug administrations rather than on its dose. The experimental studies made it possible to successfully apply peritol to the treatment of inpatients suffering from Icenko-Cushing's disease. Almost 60% of the inpatients manifested a remission, which was confirmed by the reduced blood content of ACTH, hydrocortisone and aldosterone.
G V Valueva, and
E V Luchitskiĭ, and
A A Iakovlev
January 1982,
Problemy endokrinologii,
G V Valueva, and
E V Luchitskiĭ, and
A A Iakovlev
January 1982,
Neuroscience and behavioral physiology,
G V Valueva, and
E V Luchitskiĭ, and
A A Iakovlev
January 1972,
Therapia Hungarica (English edition),
G V Valueva, and
E V Luchitskiĭ, and
A A Iakovlev
January 1992,
Klinicheskaia meditsina,
G V Valueva, and
E V Luchitskiĭ, and
A A Iakovlev
January 1970,
Problemy endokrinologii,
G V Valueva, and
E V Luchitskiĭ, and
A A Iakovlev
January 1967,
Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952),
G V Valueva, and
E V Luchitskiĭ, and
A A Iakovlev
December 1972,
Meditsinskaia radiologiia,
G V Valueva, and
E V Luchitskiĭ, and
A A Iakovlev
January 1955,
Akusherstvo i ginekologiia,
G V Valueva, and
E V Luchitskiĭ, and
A A Iakovlev
June 1985,
Experimental and clinical endocrinology,
G V Valueva, and
E V Luchitskiĭ, and
A A Iakovlev
June 1964,
Klinicheskaia meditsina,
