-transparent.png){kind=logo}
Effects of indomethacin (1.25 mg/kg) and aspirin (20 mg/kg) on testosterone-induced (0.25 mg/rat), and of indomethacin on dihydrotestosterone-induced (0.25 mg/rat) mitotic activity of the seminal vesicles and the ventral prostate in rats were examined. The results demonstrate that the seminal vesicles' proliferative reaction induced by testosterone was suppressed by treatment with indomethacin and aspirin; whereas, in the ventral prostate, the mitogenic effect of testosterone was not blocked by either of these inhibitors of prostaglandin synthesis. Cellular proliferation induced by dihydrotestosterone was not inhibited by indomethacin in either the seminal vesicles or the ventral prostate. These results suggest the existence of different mechanisms of proliferative reactions of the seminal vesicles and the ventral prostate to testosterone. The results further suggest an involvement of prostaglandins in the mitogenic effect of testosterone on the seminal vesicles.
K Lysoń, and
M Pawlikowski
October 1984,
Experimental and clinical endocrinology,
K Lysoń, and
M Pawlikowski
September 1980,
Endocrinologia experimentalis,
K Lysoń, and
M Pawlikowski
March 1973,
Prostaglandins,
K Lysoń, and
M Pawlikowski
June 1964,
Science (New York, N.Y.),
K Lysoń, and
M Pawlikowski
May 1984,
Immunobiology,
K Lysoń, and
M Pawlikowski
April 2006,
Cell biology international,
K Lysoń, and
M Pawlikowski
March 1976,
Endocrinology,
K Lysoń, and
M Pawlikowski
June 1988,
Brain research,
K Lysoń, and
M Pawlikowski
March 1976,
Lipids,
K Lysoń, and
M Pawlikowski
January 1969,
Naunyn-Schmiedebergs Archiv fur Pharmakologie,
