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To examine whether the injection of bovine TSH (bTSH) produces maximal radioactive iodine uptake (RAIU) in lung metastases in patients with differentiated thyroid cancer, 10 patients were studied 12 times. In 10 of these studies, an initial RAIU measurement was performed immediately after 3 injections of 10 IU bTSH given immediately after T3 withdrawal. Another RAIU measurement was performed 7-19 days after T3 withdrawal. Uptake increased in all patients even when it was clearly detectable immediately after bTSH stimulation. Thus, 3 days of bTSH stimulation in these patients did not lead to maximal 131I uptake, and it could only be reached after prolonged endogenous TSH stimulation. bTSH was not injected in the 2 other patients, in whom 6 RAIU measurements were carried out. Radioiodine uptake increased with time in both patients. It appears that both the level of endogenous TSH and the length of stimulation play a determining role in RAIU. This might explain why 3 days of bTSH stimulation are insufficient to elicit maximal 131I uptake.
M Schlumberger, and
P Charbord, and
P Fragu, and
P Gardet, and
J Lumbroso, and
C Parmentier, and
M Tubiana
December 1985,
Clinical nuclear medicine,
M Schlumberger, and
P Charbord, and
P Fragu, and
P Gardet, and
J Lumbroso, and
C Parmentier, and
M Tubiana
June 1977,
The Journal of clinical endocrinology and metabolism,
M Schlumberger, and
P Charbord, and
P Fragu, and
P Gardet, and
J Lumbroso, and
C Parmentier, and
M Tubiana
January 2012,
Revista espanola de medicina nuclear e imagen molecular,
M Schlumberger, and
P Charbord, and
P Fragu, and
P Gardet, and
J Lumbroso, and
C Parmentier, and
M Tubiana
June 2004,
Thyroid : official journal of the American Thyroid Association,
M Schlumberger, and
P Charbord, and
P Fragu, and
P Gardet, and
J Lumbroso, and
C Parmentier, and
M Tubiana
September 2008,
The New England journal of medicine,
M Schlumberger, and
P Charbord, and
P Fragu, and
P Gardet, and
J Lumbroso, and
C Parmentier, and
M Tubiana
January 2012,
Journal of thyroid research,
M Schlumberger, and
P Charbord, and
P Fragu, and
P Gardet, and
J Lumbroso, and
C Parmentier, and
M Tubiana
January 2000,
Rays,
M Schlumberger, and
P Charbord, and
P Fragu, and
P Gardet, and
J Lumbroso, and
C Parmentier, and
M Tubiana
April 2008,
Clinical endocrinology,
M Schlumberger, and
P Charbord, and
P Fragu, and
P Gardet, and
J Lumbroso, and
C Parmentier, and
M Tubiana
March 2010,
Thyroid : official journal of the American Thyroid Association,
M Schlumberger, and
P Charbord, and
P Fragu, and
P Gardet, and
J Lumbroso, and
C Parmentier, and
M Tubiana
January 2004,
The Journal of clinical endocrinology and metabolism,
