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Differential effects of d,l-amphetamine on licking maintained by electrical hypothalamic stimulation and/or water in rats. 1983

S N Kundu, and A J Greenshaw, and J Bures

The role of the reinforcer as a determinant of the behavioural effects of amphetamine was assessed with a procedure under which response requirements were equated. Eight rats were trained to lick on fixed-ratio schedules of rewarding lateral hypothalamic stimulation and water delivery, respectively. The effects of d,l-amphetamine (0.2-2.0 mg/kg) were investigated in the lateral hypothalamic stimulation condition and compared with the effects of the drug at 1.0 mg/kg in the water condition. Licking maintained by hypothalamic stimulation was increased after amphetamine administration to approximately 200% of control performance at 1.0 mg/kg. At this dose amphetamine administration resulted in a decrease in water maintained licking. A computer analysis of the temporal patterning of licking in both water and stimulation conditions was carried out. This analysis revealed that amphetamine may attenuate the disruptive effects of hypothalamic stimulation on the lick-interrupt cycle. The differential effects of amphetamine on licking maintained by the two events may reflect either unequal participation of catecholaminergic circuits in the two types of reward, or anti-inhibitory motor effects of amphetamine.

UI MeSH Term Description Entries
D007026 Hypothalamic Area, Lateral Area in the hypothalamus bounded medially by the mammillothalamic tract and the anterior column of the FORNIX (BRAIN). The medial edge of the INTERNAL CAPSULE and the subthalamic region form its lateral boundary. It contains the lateral hypothalamic nucleus, tuberomammillary nucleus, lateral tuberal nuclei, and fibers of the MEDIAL FOREBRAIN BUNDLE. Lateral Hypothalamic Area,Lateral Hypothalamic Nucleus,Tuberomammillary Nucleus,Accessory Nucleus of the Ventral Horn,Area Hypothalamica Lateralis,Area Lateralis Hypothalami,Lateral Hypothalamus,Lateral Tuberal Nuclei,Lateral Tuberal Nucleus,Area Hypothalamica Laterali,Area Lateralis Hypothalamus,Area, Lateral Hypothalamic,Areas, Lateral Hypothalamic,Hypothalami, Area Lateralis,Hypothalamic Areas, Lateral,Hypothalamic Nucleus, Lateral,Hypothalamica Laterali, Area,Hypothalamica Lateralis, Area,Hypothalamus, Area Lateralis,Hypothalamus, Lateral,Lateral Hypothalamic Areas,Laterali, Area Hypothalamica,Lateralis Hypothalami, Area,Lateralis Hypothalamus, Area,Lateralis, Area Hypothalamica,Nuclei, Lateral Tuberal,Nucleus, Lateral Hypothalamic,Nucleus, Lateral Tuberal,Nucleus, Tuberomammillary,Tuberal Nuclei, Lateral,Tuberal Nucleus, Lateral
D008297 Male Males
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D004326 Drinking The consumption of liquids. Water Consumption,Water Intake,Drinkings
D004558 Electric Stimulation Use of electric potential or currents to elicit biological responses. Stimulation, Electric,Electrical Stimulation,Electric Stimulations,Electrical Stimulations,Stimulation, Electrical,Stimulations, Electric,Stimulations, Electrical
D000661 Amphetamine A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE. Desoxynorephedrin,Levoamphetamine,Phenopromin,l-Amphetamine,Amfetamine,Amphetamine Sulfate,Amphetamine Sulfate (2:1),Centramina,Fenamine,Mydrial,Phenamine,Thyramine,levo-Amphetamine,Sulfate, Amphetamine,l Amphetamine,levo Amphetamine
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001522 Behavior, Animal The observable response an animal makes to any situation. Autotomy Animal,Animal Behavior,Animal Behaviors
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

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