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We studied the lavage fluid recovered from a symptomatic patient with pulmonary alveolar proteinosis using in vitro assays for macrophage function. The alveolar macrophages from this patient had reduced phagocytic capacity. The particulate fraction from the cell-free lavage fluid (20,000 X gravity pellet) induced a pronounced phagocytic defect in normal mouse peritoneal macrophages but did not impair intracellular degradative activity. These results suggest that the lipoproteinaceous debris in patients with alveolar proteinosis can induce a phagocytic defect in alveolar macrophages, which probably increases the accumulation of more debris and may contribute to the increased risk of pulmonary infection.
K M Nugent, and
E L Pesanti
December 1970,
The American review of respiratory disease,
K M Nugent, and
E L Pesanti
May 1990,
Nihon Kyobu Shikkan Gakkai zasshi,
K M Nugent, and
E L Pesanti
April 2015,
The New England journal of medicine,
K M Nugent, and
E L Pesanti
June 2012,
Respiratory research,
K M Nugent, and
E L Pesanti
August 1979,
Chest,
K M Nugent, and
E L Pesanti
March 1968,
The Annals of thoracic surgery,
K M Nugent, and
E L Pesanti
January 1993,
Vojnosanitetski pregled,
K M Nugent, and
E L Pesanti
April 1963,
The Indian journal of child health,
K M Nugent, and
E L Pesanti
January 1994,
Ryoikibetsu shokogun shirizu,
