BIOMAT Database Logo BIOMAT Database Logo

Fluoro-substituted N-nitrosamines. 6. carcinogenicity of N-nitroso-(2,2,2-trifluoroethyl)-ethylamine in rats. 1983

R Preussmann, and M Habs, and H Habs, and D Stummeyer

N-Nitroso-(2,2,2-trifluoroethyl)ethylamine (F-3-NDEA) was tested for carcinogenic activity in male Sprague-Dawley rats at 4 dose levels. The compound was given by gavage twice weekly. Treatment related tumors were observed in all experimental groups and appropriate dose-response relations were seen. The main tumor localisations were the esophagus and the nasal cavity. F-3-NDEA therefore is carcinogenic in rats after oral administration, a biological effect to be expected since it had been shown earlier that this compound is enzymatically activated by dealkylation and is weakly mutagenic in bacterial assay systems. A change in organotropism is observed when comparing carcinogenicity of F-3-NDEA with the predominantly hepatocarcinogenic activity of parent N-nitrosodiethylamine.

UI MeSH Term Description Entries
D007928 Lethal Dose 50 The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population. LD50,Dose 50, Lethal
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008168 Lung Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood. Lungs
D008297 Male Males
D009296 Nasal Cavity The proximal portion of the respiratory passages on either side of the NASAL SEPTUM. Nasal cavities, extending from the nares to the NASOPHARYNX, are lined with ciliated NASAL MUCOSA. Nasal Cavities,Cavities, Nasal,Cavity, Nasal
D009336 Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
D009603 Nitroso Compounds Organic compounds containing the nitroso (-N Compounds, Nitroso
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D002273 Carcinogens Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D004947 Esophagus The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.

Related Publications

R Preussmann, and M Habs, and H Habs, and D Stummeyer
Fluoro-substituted N-nitrosamines. 7. Non-genotoxic N-nitroso-bis(2,2,2-trifluoroethyl)amine and N-nitroso-bis(2,2,3,3,4,4,4-heptafluorobutyl)amine: binding to cytochrome P-450, acidity of alpha-protons and pharmacokinetic investigations.
January 1985, Carcinogenesis,
R Preussmann, and M Habs, and H Habs, and D Stummeyer
Preparation and biological actions of N-2,2,2-trifluoroethyl-2-(3,4-dihydroxyphenyl)ethylamine.
February 1980, Journal of pharmaceutical sciences,
R Preussmann, and M Habs, and H Habs, and D Stummeyer
Low-temperature crystallization and structure determination of N-(trifluoromethyl)formamide, N-(2,2,2-trifluoroethyl)formamide and 2,2,2-trifluoroethyl isocyanide.
February 1999, Acta crystallographica. Section B, Structural science,
R Preussmann, and M Habs, and H Habs, and D Stummeyer
Carcinogenicity of N-nitroso-3,4-dichloro- and n-nitroso-3,4-dibromopiperidine in rats.
November 1975, Cancer research,
R Preussmann, and M Habs, and H Habs, and D Stummeyer
Carcinogenicity of deuterium-labeled N-nitroso-N-methylcyclohexylamine in rats.
June 1980, Journal of the National Cancer Institute,
R Preussmann, and M Habs, and H Habs, and D Stummeyer
Carcinogenicity of N-nitroso derivatives of N-methylcarbamate insecticides in rats.
December 1978, Ecotoxicology and environmental safety,
R Preussmann, and M Habs, and H Habs, and D Stummeyer
[Carcinogenicity of N-nitroso compounds].
January 1976, Annales de la nutrition et de l'alimentation,
R Preussmann, and M Habs, and H Habs, and D Stummeyer
Fluoro-substituted N-nitrosamines. 3. Microsomal metabolism of N-nitrosodibutylamine and of fluorinated analogs.
January 1982, Carcinogenesis,
R Preussmann, and M Habs, and H Habs, and D Stummeyer
N-Nitrosamines (15 listings): N-Nitroso-N-methylurea.
January 2011, Report on carcinogens : carcinogen profiles,
R Preussmann, and M Habs, and H Habs, and D Stummeyer
N-Nitrosamines (15 listings): N-Nitroso-N-ethylurea.
January 2011, Report on carcinogens : carcinogen profiles,
Copied contents to your clipboard!