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Acutely administered ethanol has been shown to inhibit the hepatic metabolism of a number of drugs. Ethanol might be expected to decrease the first-pass extraction of chlormethiazole leading to higher blood levels of this high clearance sedative frequently used in the management of alcoholic patients. Chlormethiazole has a narrow therapeutic index and the unexpected deaths reported in alcoholics taking this drug may have been due to an effect of ethanol on the metabolism of chlormethiazole. However in this study, acutely administered ethanol maintained at levels around 22 mmol/l had no significant effect on the disposition or elimination of either daily or intravenously administered chlormethiazole.
R W Bury, and
P V Desmond, and
M L Mashford, and
B Westwood, and
G Shaw, and
K J Breen
March 2007,
Alcohol (Fayetteville, N.Y.),
R W Bury, and
P V Desmond, and
M L Mashford, and
B Westwood, and
G Shaw, and
K J Breen
January 1972,
Comptes rendus des seances de la Societe de biologie et de ses filiales,
R W Bury, and
P V Desmond, and
M L Mashford, and
B Westwood, and
G Shaw, and
K J Breen
January 1989,
Alcohol (Fayetteville, N.Y.),
R W Bury, and
P V Desmond, and
M L Mashford, and
B Westwood, and
G Shaw, and
K J Breen
September 1991,
Toxicology letters,
R W Bury, and
P V Desmond, and
M L Mashford, and
B Westwood, and
G Shaw, and
K J Breen
March 1975,
The American journal of digestive diseases,
R W Bury, and
P V Desmond, and
M L Mashford, and
B Westwood, and
G Shaw, and
K J Breen
January 2000,
Alcohol and alcoholism (Oxford, Oxfordshire),
R W Bury, and
P V Desmond, and
M L Mashford, and
B Westwood, and
G Shaw, and
K J Breen
January 1975,
Pharmacology,
R W Bury, and
P V Desmond, and
M L Mashford, and
B Westwood, and
G Shaw, and
K J Breen
March 1980,
The Journal of laboratory and clinical medicine,
R W Bury, and
P V Desmond, and
M L Mashford, and
B Westwood, and
G Shaw, and
K J Breen
October 1984,
Deutsche medizinische Wochenschrift (1946),
R W Bury, and
P V Desmond, and
M L Mashford, and
B Westwood, and
G Shaw, and
K J Breen
March 1992,
Journal of forensic sciences,
