-transparent.png){kind=logo}
The effects of chronic mild restraint on the susceptibility of the rat gastric mucosa to ethanol or cold-restraint injury were studied. Gastric mucosas of animals subjected to chronic mild restraint exhibited less damage when bathed with 40% ethanol than those of control animals. This reduced damage was observed with 2 days of mild restraint and was maximal (93% less damage; p less than 0.0005) when the animal was mildly restrained for 10 days. Pretreatment with indomethacin abolished the protection afforded by chronic mild restraint, suggesting a mechanism involving endogenous prostaglandin synthesis. Chronic mild restraint significantly (p less than 0.05) reduced the injury to the gastric mucosa caused by cold-restraint stress. This model of mild restraint may prove useful in future studies on the mechanism of stress-induced and other gastric mucosal lesions.
J L Wallace, and
N S Track, and
M M Cohen
June 1989,
The Journal of surgical research,
J L Wallace, and
N S Track, and
M M Cohen
April 2011,
Natural product research,
J L Wallace, and
N S Track, and
M M Cohen
March 1981,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
J L Wallace, and
N S Track, and
M M Cohen
September 2011,
European journal of pharmacology,
J L Wallace, and
N S Track, and
M M Cohen
November 1994,
Canadian journal of physiology and pharmacology,
J L Wallace, and
N S Track, and
M M Cohen
November 2016,
Alcohol (Fayetteville, N.Y.),
J L Wallace, and
N S Track, and
M M Cohen
November 2000,
Life sciences,
J L Wallace, and
N S Track, and
M M Cohen
January 1990,
Eicosanoids,
J L Wallace, and
N S Track, and
M M Cohen
November 1984,
Laboratory investigation; a journal of technical methods and pathology,
J L Wallace, and
N S Track, and
M M Cohen
August 1982,
The Journal of laboratory and clinical medicine,
