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The cytoplasmic receptors for 17 beta-estradiol (ER) and progesterone (PR) were measured in 39 malignant and 15 benign ovarian neoplasms. All eight endometroid carcinomas had positive ER sites, one-half contained PR. The number of ER binding sites decreased as tumor grade increased. Conversely, none of the 11 mucinous tumors contained either ER or PR receptors. One-half of the well-differentiated serous tumors had ER (57 +/- 23 fmole/mg protein) while none of the poorly differentiated tumors had measurable binding. In serous carcinomas, PR was only detected in well-differentiated lesions (447 +/- 240 fmole/mg protein). Only one of 15 benign neoplasms contained ER and PR receptors. Correlation of tumor grade and type may help to plan hormonal therapies in advanced ovarian malignancies.
L C Ford, and
J S Berek, and
L D Lagasse, and
N F Hacker, and
Y Heins, and
F Esmailian, and
R S Leuchter, and
R J DeLange
December 1983,
Geburtshilfe und Frauenheilkunde,
L C Ford, and
J S Berek, and
L D Lagasse, and
N F Hacker, and
Y Heins, and
F Esmailian, and
R S Leuchter, and
R J DeLange
April 1981,
JAMA,
L C Ford, and
J S Berek, and
L D Lagasse, and
N F Hacker, and
Y Heins, and
F Esmailian, and
R S Leuchter, and
R J DeLange
February 1990,
Cancer,
L C Ford, and
J S Berek, and
L D Lagasse, and
N F Hacker, and
Y Heins, and
F Esmailian, and
R S Leuchter, and
R J DeLange
January 1985,
Jugoslavenska ginekologija i perinatologija,
L C Ford, and
J S Berek, and
L D Lagasse, and
N F Hacker, and
Y Heins, and
F Esmailian, and
R S Leuchter, and
R J DeLange
June 2004,
Molecular and cellular endocrinology,
L C Ford, and
J S Berek, and
L D Lagasse, and
N F Hacker, and
Y Heins, and
F Esmailian, and
R S Leuchter, and
R J DeLange
October 1990,
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
L C Ford, and
J S Berek, and
L D Lagasse, and
N F Hacker, and
Y Heins, and
F Esmailian, and
R S Leuchter, and
R J DeLange
February 1986,
Gynecologic oncology,
L C Ford, and
J S Berek, and
L D Lagasse, and
N F Hacker, and
Y Heins, and
F Esmailian, and
R S Leuchter, and
R J DeLange
October 1983,
Gynecologic oncology,
L C Ford, and
J S Berek, and
L D Lagasse, and
N F Hacker, and
Y Heins, and
F Esmailian, and
R S Leuchter, and
R J DeLange
June 1992,
Minerva ginecologica,
L C Ford, and
J S Berek, and
L D Lagasse, and
N F Hacker, and
Y Heins, and
F Esmailian, and
R S Leuchter, and
R J DeLange
September 1989,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
