Biomaterial Database

Dietary NaCl loads promote calciuria and bone loss in adult oophorectomized rats consuming a low calcium diet. 1983

A Goulding, and D Campbell

This study was undertaken to determine whether dietary supplements of NaCl would exaggerate osteopenia in oophorectomized (OOPX) rats consuming a low calcium (0.01% Ca) diet. Thirty 300 g OOPX rats with 45Ca-labeled bones were studied. Animals in group 1 were killed at the start of the experiment, whereas those in groups 2 and 3 were fed a low calcium diet for 2 months. Group 3 rats received NaCl (8 g/100 g diet). Salt increased the urinary excretion of sodium, calcium, phosphate, cyclic AMP, 45Ca and hydroxyproline but did not augment fecal excretion of calcium or 45Ca. Salt caused bone loss. The femora of NaCl-treated rats contained less 45Ca, less calcium, less phosphate and less mineral ash than those of rats killed at the start of the experiment. It is suggested that in OOPX rats consuming a low calcium diet, increased NaCl intake causes decreased renal tubular reabsorption of calcium and consequently lowered plasma Ca++. This results in stimulation of parathyroid hormone secretion and thus increased bone resorption. We conclude that NaCl supplements exacerbate osteopenia in adult OOPX rats consuming a low calcium diet. The effects of high dietary salt intakes on bone loss in postmenopausal women deserve further study.

UI	MeSH Term	Description	Entries
D001842	Bone and Bones	A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principal cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.	Bone Tissue,Bone and Bone,Bone,Bones,Bones and Bone,Bones and Bone Tissue,Bony Apophyses,Bony Apophysis,Condyle,Apophyses, Bony,Apophysis, Bony,Bone Tissues,Condyles,Tissue, Bone,Tissues, Bone
D002118	Calcium	A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.	Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002369	Castration	Surgical removal or artificial destruction of gonads.	Gonadectomy,Castrations,Gonadectomies
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D004573	Electrolytes	Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)	Electrolyte
D005243	Feces	Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012965	Sodium Chloride	A ubiquitous sodium salt that is commonly used to season food.	Sodium Chloride, (22)Na,Sodium Chloride, (24)NaCl
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus