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Pulmonary disease has been associated with several chemotherapeutic agents but has not been reported in patients receiving the alkylating agent mitomycin (Mutamycin). We describe here the cases of three patients who developed interstitial pneumonia while receiving mitomycin therapy. Their clinical features including dyspnea, cough, and occasionally fever; reticular infiltrates were seen on chest roentgenogram. Histologically, diffuse alveolar septal edema, mononuclear-cell interstitial infiltrates, hypertrophy of alveolar lining cells, and alveolar septal collagen deposition were characteristic. Treatment with corticosteroids was associated with a rapid therapeutic response in all three patients.
E S Orwoll, and
P J Kiessling, and
J R Patterson
January 2010,
Respiration; international review of thoracic diseases,
E S Orwoll, and
P J Kiessling, and
J R Patterson
July 2002,
Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society,
E S Orwoll, and
P J Kiessling, and
J R Patterson
January 1979,
Annals of internal medicine,
E S Orwoll, and
P J Kiessling, and
J R Patterson
January 1983,
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E S Orwoll, and
P J Kiessling, and
J R Patterson
January 2006,
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E S Orwoll, and
P J Kiessling, and
J R Patterson
January 1995,
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E S Orwoll, and
P J Kiessling, and
J R Patterson
January 1967,
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E S Orwoll, and
P J Kiessling, and
J R Patterson
September 1953,
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E S Orwoll, and
P J Kiessling, and
J R Patterson
July 2003,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
E S Orwoll, and
P J Kiessling, and
J R Patterson
August 2001,
Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine,
