-transparent.png){kind=logo}
The agent, 1,3-bis(3-chloroethyl)-1-nitrosourea (BCNU), when given by arterial infusion for brain tumor chemotherapy is usually dissolved in an alcohol/saline solution. The authors compared the osmolality of and drug recovery from solvent systems of alcohol/saline, dimethyl sulfoxide (DMSO)/water, and dextrose/water. Recovery of drug was adequate from all solvent systems, although variability of drug recovery from the alcohol/saline and DMSO/water systems was greater than from the dextrose/water system. The alcohol/saline system was significantly hyperosmolar. The alcohol/saline and DMSO/water solvent systems offer no advantage over the dextrose/water system and may be associated with significant disadvantages.
R L Ross, and
J P Kapp, and
F Hochberg, and
I S Krull, and
X D Ding, and
C Selavka
June 1995,
Mutation research,
R L Ross, and
J P Kapp, and
F Hochberg, and
I S Krull, and
X D Ding, and
C Selavka
December 1980,
Neurosurgery,
R L Ross, and
J P Kapp, and
F Hochberg, and
I S Krull, and
X D Ding, and
C Selavka
July 1978,
Cancer,
R L Ross, and
J P Kapp, and
F Hochberg, and
I S Krull, and
X D Ding, and
C Selavka
September 1974,
Biochemical and biophysical research communications,
R L Ross, and
J P Kapp, and
F Hochberg, and
I S Krull, and
X D Ding, and
C Selavka
March 1980,
Cancer,
R L Ross, and
J P Kapp, and
F Hochberg, and
I S Krull, and
X D Ding, and
C Selavka
August 1971,
The New England journal of medicine,
R L Ross, and
J P Kapp, and
F Hochberg, and
I S Krull, and
X D Ding, and
C Selavka
August 1981,
Cancer,
R L Ross, and
J P Kapp, and
F Hochberg, and
I S Krull, and
X D Ding, and
C Selavka
April 2002,
Biochemical pharmacology,
R L Ross, and
J P Kapp, and
F Hochberg, and
I S Krull, and
X D Ding, and
C Selavka
January 1992,
Cancer immunology, immunotherapy : CII,
R L Ross, and
J P Kapp, and
F Hochberg, and
I S Krull, and
X D Ding, and
C Selavka
October 1982,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
