-transparent.png){kind=logo}
The dynamics of five plasma steroids were studied by CPB and RIA in twenty patients with Cushing's syndrome of differing etiologies: pituitary induced adrenal hyperplasia (10), recurrence after adrenal surgery or pituitary irradiation (4), adrenal carcinoma (4) and adrenal adenoma (2). Basal mean values of plasma steroids, showed increase of cortisol in hyperplasia and cancer groups, increase of 17-hydroxyprogesterone (17-OH-P) in recurrence and cancer groups and decrease of testosterone in male patients. In hyperplasia, the changes in 11-desoxycortisol and 17-OH-P (respectively by CPB assay and RIA after LH-20-Sephadex separation) were the reverse of those for cortisol 2 h and 24 h after metyrapone administration. Adrenalectomy determined in all but one patients, significant decrease of cortisol and in male patients, parallel gradual increase of testosterone.
M Luisi, and
F Franchi, and
D Drafta, and
E Stroe
January 2016,
Recent patents on endocrine, metabolic & immune drug discovery,
M Luisi, and
F Franchi, and
D Drafta, and
E Stroe
July 1994,
The Clinical investigator,
M Luisi, and
F Franchi, and
D Drafta, and
E Stroe
June 1958,
Acta endocrinologica,
M Luisi, and
F Franchi, and
D Drafta, and
E Stroe
September 2019,
The Journal of steroid biochemistry and molecular biology,
M Luisi, and
F Franchi, and
D Drafta, and
E Stroe
January 2013,
The West Indian medical journal,
M Luisi, and
F Franchi, and
D Drafta, and
E Stroe
January 1972,
Acta medica Scandinavica,
M Luisi, and
F Franchi, and
D Drafta, and
E Stroe
January 2014,
The Pan African medical journal,
M Luisi, and
F Franchi, and
D Drafta, and
E Stroe
April 2022,
European journal of rheumatology,
M Luisi, and
F Franchi, and
D Drafta, and
E Stroe
June 1961,
The Journal of clinical endocrinology and metabolism,
M Luisi, and
F Franchi, and
D Drafta, and
E Stroe
August 1977,
The Journal of clinical endocrinology and metabolism,
