BIOMAT Database Logo BIOMAT Database Logo

Reduction of bile acid loss in cystic fibrosis by dietary means. 1978

C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson

On a 'normal' diet increased faecal bile acid excretion was found in 14 of 16 children with cystic fibrosis who had steatorrhoea, but excretion was normal in 2 such children without steatorrhoea. The 16 children with steatorrhoea took 3 regimens of diet and therapy: a 'normal' diet with pancreatic enzyme supplements, a diet of reduced long-chain triglycerides with added medium-chain triglycerides, and the same diet with added pancreatic enzyme supplements. On each of these three regimens steatorrhoea and faecal bile acid loss were significantly less than on no treatment, with the lowest excretions occurring on the diet of reduced long-chain triglycerides with added medium-chain triglycerides and pancreatic enzyme supplements. Although a reduction in steatorrhoea was nearly always accompanied by a decrease in bile acid excretion, the initial bile acid loss was very variable and could not be predicted for any given degree of steatorrhoea. This suggests that at least one other factor, possibly liver disease or bile acid pool size, influences bile acid loss in the faeces.

UI MeSH Term Description Entries
D010194 Pancreatin A mammalian pancreatic extract composed of enzymes with protease, amylase and lipase activities. It is used as a digestant in pancreatic malfunction. Panteric,Panzytrat
D002446 Celiac Disease A malabsorption syndrome that is precipitated by the ingestion of foods containing GLUTEN, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION. Gluten Enteropathy,Sprue, Celiac,Sprue, Nontropical,Celiac Sprue,Gluten-Sensitive Enteropathy,Sprue,Disease, Celiac,Enteropathies, Gluten,Enteropathies, Gluten-Sensitive,Enteropathy, Gluten,Enteropathy, Gluten-Sensitive,Gluten Enteropathies,Gluten Sensitive Enteropathy,Gluten-Sensitive Enteropathies,Nontropical Sprue
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D003550 Cystic Fibrosis An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION. Mucoviscidosis,Cystic Fibrosis of Pancreas,Fibrocystic Disease of Pancreas,Pancreatic Cystic Fibrosis,Pulmonary Cystic Fibrosis,Cystic Fibrosis, Pancreatic,Cystic Fibrosis, Pulmonary,Fibrosis, Cystic,Pancreas Fibrocystic Disease,Pancreas Fibrocystic Diseases
D005243 Feces Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001647 Bile Acids and Salts Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones. Bile Acid,Bile Salt,Bile Salts,Bile Acids,Acid, Bile,Acids, Bile,Salt, Bile,Salts, Bile
D014280 Triglycerides An ester formed from GLYCEROL and three fatty acid groups. Triacylglycerol,Triacylglycerols,Triglyceride

Related Publications

C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson
Bile acid secretion in cystic fibrosis.
April 1987, Gut,
C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson
Bile acid malabsorption in cystic fibrosis.
August 1974, Nutrition reviews,
C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson
Faecal bile acid and dietary residue excretion in cystic fibrosis: age group variations.
September 1998, Journal of pediatric gastroenterology and nutrition,
C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson
Intestinal bile acid malabsorption in cystic fibrosis.
August 1993, Gut,
C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson
Aspects of bile acid metabolism in cystic fibrosis.
October 1975, Archives of disease in childhood,
C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson
Detection of bile acid loss by means of labelled bile acids. Preliminary results.
January 1972, Folia medica Neerlandica,
C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson
Bile acid metabolism in children with cystic fibrosis.
January 1985, Acta paediatrica Scandinavica. Supplement,
C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson
Postprandial total serum bile acid concentrations in cystic fibrosis.
January 1979, Monographs in paediatrics,
C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson
Serum bile acid composition in patients with cystic fibrosis.
September 1985, Clinica chimica acta; international journal of clinical chemistry,
C A Smalley, and G A Brown, and M E Parkes, and H Tease, and V Brookes, and C M Anderson
Cystic fibrosis: bile secretion.
October 1992, British medical bulletin,
Copied contents to your clipboard!