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Platelet aggregation was measured in rat and human platelet-rich plasma (PRP) after the addition of various amounts of arachidonic acid (AA), prostaglandin H2 (PGH2), adenosine diphosphate (ADP), or collagen. AA but not PGH2 caused rat platelets to aggregate in citrated or heparinized PRP. Both AA and PGH2 produced significant amounts of thromboxane A2 (TxA2) measured as thromboxane B2 (TxB2). The lack of aggregation of rat platelets with PGH2 was not due to the formation of an inhibitor of aggregation such as a prostaglandin. Thus, the formation of TxA2 may not be necessary for aggregation of rat platelets. Human platelets were aggregated by PGH2 with the concomitant formation of TxB2.
E E Nishizawa, and
D J Williams, and
C L Connell
April 1982,
British journal of pharmacology,
E E Nishizawa, and
D J Williams, and
C L Connell
January 1986,
British journal of pharmacology,
E E Nishizawa, and
D J Williams, and
C L Connell
January 2002,
Thrombosis and haemostasis,
E E Nishizawa, and
D J Williams, and
C L Connell
September 1977,
Nature,
E E Nishizawa, and
D J Williams, and
C L Connell
March 1982,
Biochemical pharmacology,
E E Nishizawa, and
D J Williams, and
C L Connell
January 1978,
Acta biologica et medica Germanica,
E E Nishizawa, and
D J Williams, and
C L Connell
December 1980,
Biochemical Society transactions,
E E Nishizawa, and
D J Williams, and
C L Connell
September 1978,
Pharmacological reviews,
E E Nishizawa, and
D J Williams, and
C L Connell
December 1990,
British journal of pharmacology,
E E Nishizawa, and
D J Williams, and
C L Connell
August 1982,
Prostaglandins,
