Biomaterial Database

Influence of fetal calf serum on the results of the E rosette test. 1983

A Naess

The sheep erythrocyte (E) rosette test was performed with and without fetal calf serum (FCS) in the medium, and using untreated and 2-amino-ethylthioisouronium bromide hydrobromide (AET)-treated E. Peripheral blood lymphocytes from 34 normal donors showed no significant difference in E rosette percentage between the tests performed with or without FCS. However, when using untreated E with FCS in the medium, patients with infectious mononucleosis and those with aseptic meningitis had a significantly decreased percentage of rosette-forming cells (RFC) as compared to the test performed without FCS. When AET-treated E were used, addition of FCS increased rosette formation of lymphocytes from patients with infectious mononucleosis, with stable multiple sclerosis and with brain tumours. Rosette formation with AET-treated E was generally increased when FCS was used, whereas decreased rosette formation was more common when FCS was used in combination with untreated E. The fact that significant differences in rosette formation associated with FCS have been found in certain patient groups, calls for caution when comparing results from laboratories that differ in the use or not of FCS.

UI	MeSH Term	Description	Entries
D007244	Infectious Mononucleosis	A common, acute infection usually caused by the Epstein-Barr virus (HERPESVIRUS 4, HUMAN). There is an increase in mononuclear white blood cells and other atypical lymphocytes, generalized lymphadenopathy, splenomegaly, and occasionally hepatomegaly with hepatitis.	Glandular Fever,Mononucleosis, Infectious,Fever, Glandular
D008214	Lymphocytes	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.	Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D008582	Meningitis, Aseptic	A syndrome characterized by headache, neck stiffness, low grade fever, and CSF lymphocytic pleocytosis in the absence of an acute bacterial pathogen. Viral meningitis is the most frequent cause although MYCOPLASMA INFECTIONS; RICKETTSIA INFECTIONS; diagnostic or therapeutic procedures; NEOPLASTIC PROCESSES; septic perimeningeal foci; and other conditions may result in this syndrome. (From Adams et al., Principles of Neurology, 6th ed, p745)	Aseptic Meningitis
D009103	Multiple Sclerosis	An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)	MS (Multiple Sclerosis),Multiple Sclerosis, Acute Fulminating,Sclerosis, Disseminated,Disseminated Sclerosis,Sclerosis, Multiple
D002417	Cattle	Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.	Beef Cow,Bos grunniens,Bos indicus,Bos indicus Cattle,Bos taurus,Cow,Cow, Domestic,Dairy Cow,Holstein Cow,Indicine Cattle,Taurine Cattle,Taurus Cattle,Yak,Zebu,Beef Cows,Bos indicus Cattles,Cattle, Bos indicus,Cattle, Indicine,Cattle, Taurine,Cattle, Taurus,Cattles, Bos indicus,Cattles, Indicine,Cattles, Taurine,Cattles, Taurus,Cow, Beef,Cow, Dairy,Cow, Holstein,Cows,Dairy Cows,Domestic Cow,Domestic Cows,Indicine Cattles,Taurine Cattles,Taurus Cattles,Yaks,Zebus
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005312	Fetal Blood	Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.	Cord Blood,Umbilical Cord Blood,Blood, Cord,Blood, Fetal,Blood, Umbilical Cord,Bloods, Cord,Bloods, Fetal,Bloods, Umbilical Cord,Cord Blood, Umbilical,Cord Bloods,Cord Bloods, Umbilical,Fetal Bloods,Umbilical Cord Bloods
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000338	beta-Aminoethyl Isothiourea	A radiation-protective agent that can inhibit DNA damage by binding to the DNA. It also increases the susceptibility of blood cells to complement-mediated lysis.	2-Aminoethylisothiuronium Bromide,beta-Aminoethylisothiuronium Diacetate,beta-Aminoethylisothiuronium Dihydrobromide,2-Aminoethylisothiuronium Diacetate,2-Aminoethylisothiuronium Dihydrochloride,2-Aminoethylisothiuronium Dihydroiodide,2-Aminoethylisothiuronium Diperchlorate,2-Aminoethylisothiuronium Monohydrobromide,2-Aminoethylisothiuronium Phosphate (1:1),2-Aminoethylisothiuronium Sulfate (1:1),AET,Aminoethylisothiuronium Bromide Hydrobromide,Carbamimidothioic acid, 2-aminoethyl ester, dihydrobromide,Isothiourea, (2-Aminoethyl),Ixecur,S-(2-Aminoethyl)isothiourea,beta-Aminoethylisothiuronium Bromide,beta-Aminoethylisothiuronium Dihydrochloride,beta-Aminoethylisothiuronium Dihydroiodide,beta-Aminoethylisothiuronium Diperchlorate,beta-Aminoethylisothiuronium Monohydrobromide,beta-Aminoethylisothiuronium Phosphate (1:1),beta-Aminoethylisothiuronium Sulfate (1:1),2 Aminoethylisothiuronium Bromide,2 Aminoethylisothiuronium Diacetate,2 Aminoethylisothiuronium Dihydrochloride,2 Aminoethylisothiuronium Dihydroiodide,2 Aminoethylisothiuronium Diperchlorate,2 Aminoethylisothiuronium Monohydrobromide,Bromide, 2-Aminoethylisothiuronium,Bromide, beta-Aminoethylisothiuronium,Diacetate, 2-Aminoethylisothiuronium,Diacetate, beta-Aminoethylisothiuronium,Dihydrobromide, beta-Aminoethylisothiuronium,Dihydrochloride, 2-Aminoethylisothiuronium,Dihydrochloride, beta-Aminoethylisothiuronium,Dihydroiodide, 2-Aminoethylisothiuronium,Dihydroiodide, beta-Aminoethylisothiuronium,Diperchlorate, 2-Aminoethylisothiuronium,Diperchlorate, beta-Aminoethylisothiuronium,Hydrobromide, Aminoethylisothiuronium Bromide,Isothiourea, beta-Aminoethyl,Monohydrobromide, 2-Aminoethylisothiuronium,Monohydrobromide, beta-Aminoethylisothiuronium,beta Aminoethyl Isothiourea,beta Aminoethylisothiuronium Bromide,beta Aminoethylisothiuronium Diacetate,beta Aminoethylisothiuronium Dihydrobromide,beta Aminoethylisothiuronium Dihydrochloride,beta Aminoethylisothiuronium Dihydroiodide,beta Aminoethylisothiuronium Diperchlorate,beta Aminoethylisothiuronium Monohydrobromide
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia