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The effect of Substance P (SP) on the intestine in situ of the dog was investigated. Five female dogs were used. At the same time, mechanographic recordings, using balloon kymography, were taken, while the myoelectric activity was recorded by means of electrography. Differences in SP action on the mechanogram and electromyogram of the stomach and the small intestines were reflected in the following phenomena: (a) SP in the doses used was less active on the ileum than on the stomach; (b) SP increased basal tonus but inhibited peristaltic contraction; (c) SP acted predominantly on spike discharges in the electromyogram. These results are likely to support the assumption that SP acts as a physiological modulator of smooth muscle activity.
K Milenov, and
P Oehme, and
M Bienert, and
J Bergmann
September 1979,
Endocrinologia experimentalis,
K Milenov, and
P Oehme, and
M Bienert, and
J Bergmann
October 1992,
Zentralblatt fur Veterinarmedizin. Reihe A,
K Milenov, and
P Oehme, and
M Bienert, and
J Bergmann
February 1985,
Fiziologicheskii zhurnal SSSR imeni I. M. Sechenova,
K Milenov, and
P Oehme, and
M Bienert, and
J Bergmann
January 2005,
Journal of cardiovascular pharmacology,
K Milenov, and
P Oehme, and
M Bienert, and
J Bergmann
January 1975,
Pharmacology,
K Milenov, and
P Oehme, and
M Bienert, and
J Bergmann
January 1975,
Pharmacology,
K Milenov, and
P Oehme, and
M Bienert, and
J Bergmann
February 1975,
Surgery, gynecology & obstetrics,
K Milenov, and
P Oehme, and
M Bienert, and
J Bergmann
January 1985,
Peptides,
K Milenov, and
P Oehme, and
M Bienert, and
J Bergmann
December 1980,
Nihon Heikatsukin Gakkai zasshi,
K Milenov, and
P Oehme, and
M Bienert, and
J Bergmann
April 1982,
European journal of pharmacology,
