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Peroxidation of membrane lipids has been implicated in the toxicity of reactive oxygen intermediates and of several hepatotoxins, but the specific products of this peroxidation in vivo have not been chemically identified. A method for the isolation, identification, and quantitation of specific lipid hydroperoxy and hydroxy acids formed in vivo has been developed. Hydroxylated derivatives of linoleic, arachidonic, and docosahexaenoic acids formed in mouse liver phosphatidylcholines following carbon tetrachloride administration were isolated by high-pressure liquid chromatography and identified as the trimethylsilyl ether methyl ester derivatives by gas chromatography-mass spectrometry. This methodology should be important for the investigation of the role of lipid peroxidation in a variety of normal physiologic and pathologic processes.
H Hughes, and
C V Smith, and
E C Horning, and
J R Mitchell
January 1993,
Journal of analytical toxicology,
H Hughes, and
C V Smith, and
E C Horning, and
J R Mitchell
July 1995,
Analytical biochemistry,
H Hughes, and
C V Smith, and
E C Horning, and
J R Mitchell
January 2000,
Rapid communications in mass spectrometry : RCM,
H Hughes, and
C V Smith, and
E C Horning, and
J R Mitchell
January 1988,
Basic life sciences,
H Hughes, and
C V Smith, and
E C Horning, and
J R Mitchell
July 2015,
Analytica chimica acta,
H Hughes, and
C V Smith, and
E C Horning, and
J R Mitchell
January 2004,
Rapid communications in mass spectrometry : RCM,
H Hughes, and
C V Smith, and
E C Horning, and
J R Mitchell
March 2010,
Se pu = Chinese journal of chromatography,
H Hughes, and
C V Smith, and
E C Horning, and
J R Mitchell
November 1994,
Free radical biology & medicine,
H Hughes, and
C V Smith, and
E C Horning, and
J R Mitchell
January 2004,
Rapid communications in mass spectrometry : RCM,
H Hughes, and
C V Smith, and
E C Horning, and
J R Mitchell
May 1990,
The Analyst,
