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Platelets labeled with Indium-111 were used to visualize polytetrafluoroethylene (PTFE) bypass grafts in vivo and to quantitate platelet deposition vs. time. The grafts were inserted into the femoral and carotid arteries of dogs and were first exposed to unlabeled blood for 0 to 3 hours. They were then imaged for up to 5 days. An index of activity, designed to correct for isotope decay and changing levels of background, was used to quantitate platelet deposition. Grafts exposed to unlabeled blood for, at most, 1 hour were visible immediately. When labeled platelets were administered to the circulation after at least 2 hours, grafts became visible only after 3 days. Continuous imaging of fresh implants, showing that platelet deposition does not increase monotonically with time, was used to explain this phenomenon. The interpretation of nuclear images of synthetic grafts depends on the delay between establishing flow in the grafts and the administration of labeled platelets.
J Megerman, and
J T Christenson, and
K C Hanel, and
H W Strauss, and
W M Abbott
December 1981,
Circulation,
J Megerman, and
J T Christenson, and
K C Hanel, and
H W Strauss, and
W M Abbott
April 1981,
The Journal of laboratory and clinical medicine,
J Megerman, and
J T Christenson, and
K C Hanel, and
H W Strauss, and
W M Abbott
February 1983,
The New England journal of medicine,
J Megerman, and
J T Christenson, and
K C Hanel, and
H W Strauss, and
W M Abbott
October 1982,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
J Megerman, and
J T Christenson, and
K C Hanel, and
H W Strauss, and
W M Abbott
November 1984,
Deutsche medizinische Wochenschrift (1946),
J Megerman, and
J T Christenson, and
K C Hanel, and
H W Strauss, and
W M Abbott
August 1988,
Laboratory animal science,
J Megerman, and
J T Christenson, and
K C Hanel, and
H W Strauss, and
W M Abbott
April 1983,
Seminars in thrombosis and hemostasis,
J Megerman, and
J T Christenson, and
K C Hanel, and
H W Strauss, and
W M Abbott
June 1978,
Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
J Megerman, and
J T Christenson, and
K C Hanel, and
H W Strauss, and
W M Abbott
January 1980,
American journal of hematology,
J Megerman, and
J T Christenson, and
K C Hanel, and
H W Strauss, and
W M Abbott
November 1984,
The Journal of the Medical Society of New Jersey,
