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Effects of calcium antagonists on the ST alternans and associated mechanical alternans during acute coronary occlusion were examined in anesthetized dogs. The heart rate was fixed by atrial pacing. The intravenous administration of 0.2 mg/kg verapamil attenuated the ST alternans as did 0.5 mg/kg diltiazem. Although these drugs significantly attenuated TQ depression during occlusion, the attenuation was observed after a longer period of occlusion and when the degree of TQ depression was comparable to that during the control occlusion. Nifedipine, 0.03 mg/kg, slightly attenuated the ST alternans, but 0.5 mg/kg dipyridamole had no effect. These results support the idea that slow inward currents are involved in the ST alternans. On the other hand, the mechanical alternans was attenuated in six of 11 dogs. It is probable that factors other than the electrical alternans may also contribute to the mechanical alternans.
H Hashimoto, and
K Suzuki, and
S Miyake, and
M Nakashima
October 1981,
British journal of pharmacology,
H Hashimoto, and
K Suzuki, and
S Miyake, and
M Nakashima
September 1992,
Catheterization and cardiovascular diagnosis,
H Hashimoto, and
K Suzuki, and
S Miyake, and
M Nakashima
March 1998,
Japanese heart journal,
H Hashimoto, and
K Suzuki, and
S Miyake, and
M Nakashima
October 1984,
The American journal of cardiology,
H Hashimoto, and
K Suzuki, and
S Miyake, and
M Nakashima
January 1991,
Indian heart journal,
H Hashimoto, and
K Suzuki, and
S Miyake, and
M Nakashima
December 1991,
The American journal of cardiology,
H Hashimoto, and
K Suzuki, and
S Miyake, and
M Nakashima
March 2001,
The Canadian journal of cardiology,
H Hashimoto, and
K Suzuki, and
S Miyake, and
M Nakashima
May 1978,
Japanese heart journal,
H Hashimoto, and
K Suzuki, and
S Miyake, and
M Nakashima
November 1980,
Pacing and clinical electrophysiology : PACE,
H Hashimoto, and
K Suzuki, and
S Miyake, and
M Nakashima
June 1989,
Cardiovascular research,
