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An unfractionated mucosal heparin preparation and a low molecular weight heparin fraction were randomly administered to rats subcutaneously. This injection was made on rats with experimentally induced venous thrombosis. At high doses (6.66 mg/kg) of both drugs, thrombus mean weight was reduced in comparison with a control group. At lower doses (2.22 mg/kg) these two drugs inhibited the growth of the thrombus. This inhibition was obtained with a lower dose (0.66 mg/kg) of the low molecular weight heparin fraction than of heparin. The low molecular weight heparin fraction (molecular weight 5,000 daltons) has a high anti-Xa activity (200 units) and a low activity determined by the USP assay (50 units).
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F Toulemonde, and
E Vairel
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Journal of leukocyte biology,
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February 1991,
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November 1988,
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September 1999,
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July 1986,
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C Doutremepuich, and
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January 2005,
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January 1984,
Acta chirurgica Scandinavica,
