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1 The kinetics of clonidine and its relation to the blood pressure response after single intravenous doses of 75 micrograms--275 micrograms in hypertensive patients were determined. 2 Clonidine disposition could be described by a two compartment open model and pharmacokinetic parameters show a rapid distribution phase of 20--30 min and a mean plasma clearance of 4.6 ml min-1 kg-1 (75--200 microgram). The half-life of the beta-phase was found to be in the range of 7.4--11.4 h. Indications of dose dependent kinetics were obtained. 3 A dose-dependent decrease in blood pressure was obtained. 4 The maximal reduction in MAP (mean arterial blood pressure) was significantly (P less than 0.01) related to plasma concentrations of clonidine. 5 The reduction in MAP was always related to plasma concentrations of clonidine (r = 0.88, P less than 0.01) when pseudoequilibrium of distribution of the drug was achieved.
M Frisk-Holmberg, and
P O Edlund, and
L Paalzow
March 1986,
Kardiologiia,
M Frisk-Holmberg, and
P O Edlund, and
L Paalzow
January 1977,
British medical journal,
M Frisk-Holmberg, and
P O Edlund, and
L Paalzow
April 1979,
Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology,
M Frisk-Holmberg, and
P O Edlund, and
L Paalzow
January 1973,
Revista espanola de cardiologia,
M Frisk-Holmberg, and
P O Edlund, and
L Paalzow
July 1974,
Arzneimittel-Forschung,
M Frisk-Holmberg, and
P O Edlund, and
L Paalzow
December 1975,
Circulation research,
M Frisk-Holmberg, and
P O Edlund, and
L Paalzow
April 1977,
Clinical pharmacology and therapeutics,
M Frisk-Holmberg, and
P O Edlund, and
L Paalzow
August 1983,
Archives internationales de pharmacodynamie et de therapie,
M Frisk-Holmberg, and
P O Edlund, and
L Paalzow
June 1992,
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan,
M Frisk-Holmberg, and
P O Edlund, and
L Paalzow
January 1977,
Acta physiologica Academiae Scientiarum Hungaricae,
