Absence of beta mRNA in beta0-thalassemia in Kurdish Jews. 1978

F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz

We report the characterization of the amount of beta mRNA in a Kurdish Jewish population with beta0-thalassemia using the same methods employed for characterization of the Catania and Ferrara beta0 patients. We found very low amounts of beta mRNA sequences, consistent with the presence of beta0-thalassemia of the beta mRNA-negative population type. In addition, no globin gene deletion was detected that could account for the absence of beta mRNA.

UI MeSH Term Description Entries
D007585 Jews An ethnic group with historical ties to the land of ISRAEL and the religion of JUDAISM. Jew
D009693 Nucleic Acid Hybridization Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503) Genomic Hybridization,Acid Hybridization, Nucleic,Acid Hybridizations, Nucleic,Genomic Hybridizations,Hybridization, Genomic,Hybridization, Nucleic Acid,Hybridizations, Genomic,Hybridizations, Nucleic Acid,Nucleic Acid Hybridizations
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005914 Globins A superfamily of proteins containing the globin fold which is composed of 6-8 alpha helices arranged in a characterstic HEME enclosing structure. Globin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated

Related Publications

F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz
November 1978, Israel journal of medical sciences,
F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz
January 1977, Hemoglobin,
F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz
January 1973, Israel journal of medical sciences,
F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz
January 1988, Hemoglobin,
F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz
June 1978, Cell,
F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz
January 1978, Hemoglobin,
F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz
November 1959, Harefuah,
F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz
June 1978, Cell,
F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz
September 1966, British journal of haematology,
F Ramirez, and D Starkman, and A Bank, and H Kerem, and G Cividalli, and E A Rachmilewitz
December 1981, Cell,
Copied contents to your clipboard!