Biomaterial Database

Antibodies against Aspergillus fumigatus in bronchial secretions from patients without aspergillosis. 1983

H Schønheyder, and P Andersen, and A T Pedersen

Antibodies to Aspergillus fumigatus were investigated by indirect immunofluorescence (IIF) and enzyme-linked immunosorbent assay (ELISA) in bronchial secretions (BS) and sera from 40 patients with neoplasia, lung infiltrates of non-fungal aetiology or chronic bronchitis. By IIF, IgG aspergillus antibodies were found in 23 samples of BS (58%) (titre range 10-40) and in all 40 sera (titre range 10-1280). IgA aspergillus antibodies were detected in 33 samples of BS (83%) (titre range 10-160) and in 33 sera (83%) (titre range 10-40). IgM aspergillus antibodies occurred in 2 samples of BS (5%) (titre 10 and 40) compared with 35 sera (88%) (titre range 10-40). Antibodies with secretory component (SC) were detected in 20 of 39 BS samples tested (51%) (titre range 10-160). Significantly higher levels of IgA antibodies were detected by ELISA in BS than in serum (2p less than 0.05) and, conversely, significantly higher levels of IgG antibodies were found in serum than in BS (2p less than 0.001). Low levels of antibodies with SC were also detected in BS by ELISA. These results suggest that aspergillus antibodies are produced within the bronchopulmonary system in patients without aspergillosis.

UI	MeSH Term	Description	Entries
D007070	Immunoglobulin A	Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.	IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D007071	Immunoglobulin A, Secretory	The principle immunoglobulin in exocrine secretions such as milk, respiratory and intestinal mucin, saliva and tears. The complete molecule (around 400 kD) is composed of two four-chain units of IMMUNOGLOBULIN A, one SECRETORY COMPONENT and one J chain (IMMUNOGLOBULIN J-CHAINS).	Colostral IgA,IgA, Exocrine,IgA, Secretory,SIgA,Secretory IgA,Secretory Immunoglobulin A,Exocrine IgA,IgA, Colostral
D007074	Immunoglobulin G	The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.	Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007075	Immunoglobulin M	A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin.	Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D001980	Bronchi	The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.	Primary Bronchi,Primary Bronchus,Secondary Bronchi,Secondary Bronchus,Tertiary Bronchi,Tertiary Bronchus,Bronchi, Primary,Bronchi, Secondary,Bronchi, Tertiary,Bronchus,Bronchus, Primary,Bronchus, Secondary,Bronchus, Tertiary
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000908	Antibodies, Fungal	Immunoglobulins produced in a response to FUNGAL ANTIGENS.	Fungal Antibodies
D001230	Aspergillus	A genus of mitosporic fungi containing about 100 species and eleven different teleomorphs in the family Trichocomaceae.