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Topical administration of nylidrin hydrochloride lowered intraocular pressure in both albino rabbits and cynomologus monkeys. The maximum decrease occurred two hours following drug application and was unilateral. The response lasted four hours in monkeys and at least six hours in rabbits. Outflow facility, episcleral venous pressure, and aqueous humor flow measured by fluorophotometry were unaltered in both species. In rabbits in the treated eyes, ocular blood flow was increased, and anterior and posterior chamber ascorbate concentrations were unchanged. The mechanism of IOP reduction appears to be increased aqueous humor outflow via uveoscleral outflow routes that are not pressure dependent.
L Sobel, and
J B Serle, and
S M Podos, and
T Krupin, and
G S Chubak, and
M E Yablonski, and
C Severin
September 1984,
Archives of ophthalmology (Chicago, Ill. : 1960),
L Sobel, and
J B Serle, and
S M Podos, and
T Krupin, and
G S Chubak, and
M E Yablonski, and
C Severin
December 2005,
Investigative ophthalmology & visual science,
L Sobel, and
J B Serle, and
S M Podos, and
T Krupin, and
G S Chubak, and
M E Yablonski, and
C Severin
October 2003,
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics,
L Sobel, and
J B Serle, and
S M Podos, and
T Krupin, and
G S Chubak, and
M E Yablonski, and
C Severin
March 2004,
Investigative ophthalmology & visual science,
L Sobel, and
J B Serle, and
S M Podos, and
T Krupin, and
G S Chubak, and
M E Yablonski, and
C Severin
August 1987,
Current eye research,
L Sobel, and
J B Serle, and
S M Podos, and
T Krupin, and
G S Chubak, and
M E Yablonski, and
C Severin
September 1995,
Current eye research,
L Sobel, and
J B Serle, and
S M Podos, and
T Krupin, and
G S Chubak, and
M E Yablonski, and
C Severin
August 1964,
Archives of ophthalmology (Chicago, Ill. : 1960),
L Sobel, and
J B Serle, and
S M Podos, and
T Krupin, and
G S Chubak, and
M E Yablonski, and
C Severin
January 1989,
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie,
L Sobel, and
J B Serle, and
S M Podos, and
T Krupin, and
G S Chubak, and
M E Yablonski, and
C Severin
November 1977,
Investigative ophthalmology & visual science,
L Sobel, and
J B Serle, and
S M Podos, and
T Krupin, and
G S Chubak, and
M E Yablonski, and
C Severin
April 1993,
Archives of ophthalmology (Chicago, Ill. : 1960),
