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Congenitally athymic (nude) mice show significant disorders of endocrine functions of the gonads and adrenals. Transplantation of the thymus to such animals in the first days of life entails the normalization of the functions of the adrenals and testes but not of the ovaries in adult animals. It is inferred that abnormalities in the functions of the testes and adrenals in nude mice are consequent on the lack of the thymus in the early stages of ontogenesis.
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