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Spleen colony forming cells (CFU-S) and agar-gel colony forming cells (CFU-C) are separate but heterogeneous cell populations, as measured by buoyant density. Myleran (MY) abrogated the major (lighter density) components of the CFU-S and CFU-C compartments, thus shifting the surviving CFU-S and CFU-C density profiles into the higher density region. The normal spleen colony erythrocytic : granulocytic (E:G) ratio profile showed three density regions with different distributions of erythroid and granulocytic colonies. The preponderantly erythrocytic colony-generating CFU-S of the intermediate density regions were eradicated by MY. Comparison of the density distribution of erythrocytic and granulocytic colony-generating CFU-S of normal bone marrow showed that the erythrocytic CFU-S profile paralleled that of total CFU-S, while most of the granulocytic CFU-S were contained in the major (and lowest density) peak. MY eradicated the two main (and lowest density) peaks of CFU-S; surviving CFU-S occurred preponderantly in a minor (higher density) peak which has a high potential for generating erythrocytic colonies.
L Delmonte, and
N Williams, and
M A Moore
July 1978,
Cell and tissue kinetics,
L Delmonte, and
N Williams, and
M A Moore
March 1973,
British journal of haematology,
L Delmonte, and
N Williams, and
M A Moore
April 1985,
Scandinavian journal of haematology,
L Delmonte, and
N Williams, and
M A Moore
January 1981,
Acta haematologica,
L Delmonte, and
N Williams, and
M A Moore
October 1976,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
L Delmonte, and
N Williams, and
M A Moore
November 1995,
Experimental hematology,
L Delmonte, and
N Williams, and
M A Moore
June 1991,
Blood,
L Delmonte, and
N Williams, and
M A Moore
January 1975,
Cell and tissue kinetics,
L Delmonte, and
N Williams, and
M A Moore
January 1988,
Blood cells,
L Delmonte, and
N Williams, and
M A Moore
January 1983,
Leukemia research,
