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Continuous intra-arterial blood pressure recording using the "Oxford" technique has been used to study the antihypertensive effects of oxprenolol taken three times daily in fully ambulatory patients with essential hypertension, outside hospital. During the first 24 h of treatment there was a reduction in daytime heart rate and a small reduction in daytime blood pressure. After 10 weeks treatment there was a more substantial fall in daytime blood pressure from the hour of waking, but no effect on sleeping nighttime blood pressure or heart rate. Twenty-four hour variation, as assessed by the amplitude of a fitted regression curve, showed a reduction in heart rate but not blood pressure variation. In 4 patients restudied after 11 weeks treatment with oxprenolol (tid) and cyclopenthiazide at 9 a.m. there was some evidence of an antihypertensive effect occurring during both the daytime and nighttime.
M W Millar-Craig, and
S Mann, and
V Bala Subramanian, and
D G Altman, and
E B Raftery
February 1989,
Journal of hypertension,
M W Millar-Craig, and
S Mann, and
V Bala Subramanian, and
D G Altman, and
E B Raftery
April 1988,
Clinical and experimental pharmacology & physiology,
M W Millar-Craig, and
S Mann, and
V Bala Subramanian, and
D G Altman, and
E B Raftery
May 1988,
The American journal of cardiology,
M W Millar-Craig, and
S Mann, and
V Bala Subramanian, and
D G Altman, and
E B Raftery
June 1988,
Archives des maladies du coeur et des vaisseaux,
M W Millar-Craig, and
S Mann, and
V Bala Subramanian, and
D G Altman, and
E B Raftery
January 1976,
La Prensa medica mexicana,
M W Millar-Craig, and
S Mann, and
V Bala Subramanian, and
D G Altman, and
E B Raftery
January 1989,
European journal of clinical pharmacology,
M W Millar-Craig, and
S Mann, and
V Bala Subramanian, and
D G Altman, and
E B Raftery
July 1990,
American heart journal,
M W Millar-Craig, and
S Mann, and
V Bala Subramanian, and
D G Altman, and
E B Raftery
April 1986,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
M W Millar-Craig, and
S Mann, and
V Bala Subramanian, and
D G Altman, and
E B Raftery
January 1977,
Bollettino della Societa italiana di cardiologia,
M W Millar-Craig, and
S Mann, and
V Bala Subramanian, and
D G Altman, and
E B Raftery
October 1998,
Atencion primaria,
