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Analbuminemic rats were found to be highly susceptible to induction of renal tumors. Thirty-nine weeks after N-dimethylnitrosamine administration, the incidence of renal tumors and average weight of kidneys (including tumors) were 76.0% and 10.8 +/- 4.1 g in male analbuminemic rats, respectively, whereas they were 37.1% and 3.5 +/- 0.1 g, respectively, in normal male SD rats.
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