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Serum calcium and magnesium levels were studied during neuroleptic treatment in a group of 29 chronic schizophrenic inpatients who had previously remained drug free for at least 4 weeks. The drug-free values of both electrolytes were not significantly different between patients and controls. In three patients who developed catatonic stupor during the drug-free period, calcium was significantly increased at the onset of the catatonic manifestations. Both electrolytes were significantly decreased in the whole group during treatment; the magnitude of the decrease was independent of the neuroleptic used. No correlation was found between the observed increase in prolactin and calcium changes. Patients who remained free of extra-pyramidal symptoms had a higher mean drug-free magnesium to calcium ratio compared to those who developed such symptoms. Our study provides evidence for an interconnection between serum electrolyte changes and neuroleptic drug action.
G Athanassenas, and
E Papadopoulos, and
A Kourkoubas, and
S Tsitourides, and
J Gabriel, and
S Hoïdas, and
E Frangos
January 1987,
Minerva psichiatrica,
G Athanassenas, and
E Papadopoulos, and
A Kourkoubas, and
S Tsitourides, and
J Gabriel, and
S Hoïdas, and
E Frangos
February 1990,
Canadian journal of psychiatry. Revue canadienne de psychiatrie,
G Athanassenas, and
E Papadopoulos, and
A Kourkoubas, and
S Tsitourides, and
J Gabriel, and
S Hoïdas, and
E Frangos
March 1947,
The Journal of clinical investigation,
G Athanassenas, and
E Papadopoulos, and
A Kourkoubas, and
S Tsitourides, and
J Gabriel, and
S Hoïdas, and
E Frangos
August 2019,
Medicina (Kaunas, Lithuania),
G Athanassenas, and
E Papadopoulos, and
A Kourkoubas, and
S Tsitourides, and
J Gabriel, and
S Hoïdas, and
E Frangos
December 1982,
Indian pediatrics,
G Athanassenas, and
E Papadopoulos, and
A Kourkoubas, and
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May 2005,
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology,
G Athanassenas, and
E Papadopoulos, and
A Kourkoubas, and
S Tsitourides, and
J Gabriel, and
S Hoïdas, and
E Frangos
November 1963,
Zentralblatt fur allgemeine Pathologie u. pathologische Anatomie,
G Athanassenas, and
E Papadopoulos, and
A Kourkoubas, and
S Tsitourides, and
J Gabriel, and
S Hoïdas, and
E Frangos
April 2002,
Headache,
G Athanassenas, and
E Papadopoulos, and
A Kourkoubas, and
S Tsitourides, and
J Gabriel, and
S Hoïdas, and
E Frangos
August 1990,
The Journal of the Association of Physicians of India,
G Athanassenas, and
E Papadopoulos, and
A Kourkoubas, and
S Tsitourides, and
J Gabriel, and
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E Frangos
January 2019,
Circulation. Genomic and precision medicine,
