-transparent.png){kind=logo}
Aromatic analogues of (E)-1-(4-carboxyphenyl)-2-methyl-4-(2,6,6-trimethyl-1-cyclohexen-1-yl)butadiene (1b) and its ethyl ester (1a) were synthesized as potential chemopreventive agents for the treatment of epithelial cancer and such skin diseases as psoriasis and cystic acne. The phenyl ring of 1 was replaced by 2-fluorophenyl, 2-methoxyphenyl, thienyl, furanyl, and pyridyl groups. The 1-fluorobutadiene analogue of 1 was also synthesized. With exception for the furanyl analogue, these compounds demonstrated good activity in reversing keratinization in hamster tracheal organ culture and in inhibiting the induction of ornithine decarboxylase in mouse epidermis by a tumor promoter.
M I Dawson, and
R Chan, and
P D Hobbs, and
W R Chao, and
L J Schiff
January 1981,
Journal of medicinal chemistry,
M I Dawson, and
R Chan, and
P D Hobbs, and
W R Chao, and
L J Schiff
January 1982,
Journal of medicinal chemistry,
M I Dawson, and
R Chan, and
P D Hobbs, and
W R Chao, and
L J Schiff
January 1971,
Journal of the Chemical Society. Perkin transactions 1,
M I Dawson, and
R Chan, and
P D Hobbs, and
W R Chao, and
L J Schiff
July 2002,
Bioorganic & medicinal chemistry,
M I Dawson, and
R Chan, and
P D Hobbs, and
W R Chao, and
L J Schiff
September 1980,
Journal of medicinal chemistry,
M I Dawson, and
R Chan, and
P D Hobbs, and
W R Chao, and
L J Schiff
September 1979,
Journal of medicinal chemistry,
M I Dawson, and
R Chan, and
P D Hobbs, and
W R Chao, and
L J Schiff
December 1980,
Journal of chromatography,
M I Dawson, and
R Chan, and
P D Hobbs, and
W R Chao, and
L J Schiff
November 1984,
Journal of medicinal chemistry,
M I Dawson, and
R Chan, and
P D Hobbs, and
W R Chao, and
L J Schiff
January 1989,
Journal of medicinal chemistry,
M I Dawson, and
R Chan, and
P D Hobbs, and
W R Chao, and
L J Schiff
August 2012,
Bioorganic & medicinal chemistry letters,
