BIOMAT Database Logo BIOMAT Database Logo

Absorption of sulfate from orally administered magnesium sulfate in man. 1983

M E Morris, and G Levy

The purpose of this investigation was to determine the suitability of orally administered magnesium sulfate as a source of inorganic sulfate for counteracting the systemic depletion of sulfate caused by large doses of acetaminophen and certain other drugs that are metabolized to sulfate conjugates. Oral administration of 13.9 g magnesium sulfate U.S.P., in 4 equal hourly increments, to seven healthy men resulted in the urinary excretion (corrected for baseline excretion rate) of an amount of inorganic sulfate equivalent to 30.2 +/- 17.2 percent (mean +/- SD) of the dose during the first 24 hours. Excretion during the subsequent 48 hours was negligible. Six of the subjects experienced loose stools or diarrhea. Compared to sodium sulfate, magnesium sulfate appears to be absorbed less completely and more erratically, and to produce more adverse effects.

UI MeSH Term Description Entries
D007408 Intestinal Absorption Uptake of substances through the lining of the INTESTINES. Absorption, Intestinal
D008278 Magnesium Sulfate A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083) Magnesium Sulfate, Heptahydrate,Heptahydrate Magnesium Sulfate,Sulfate, Magnesium
D008297 Male Males
D003404 Creatinine Creatinine Sulfate Salt,Krebiozen,Salt, Creatinine Sulfate,Sulfate Salt, Creatinine
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations
D013431 Sulfates Inorganic salts of sulfuric acid. Sulfate,Sulfates, Inorganic,Inorganic Sulfates

Related Publications

M E Morris, and G Levy
Absorption of magnesium from orally administered magnesium sulfate in man.
January 1987, Journal of toxicology. Clinical toxicology,
M E Morris, and G Levy
Absorption of orally administered sodium sulfate in humans.
March 1981, Journal of pharmaceutical sciences,
M E Morris, and G Levy
Lymphatic absorption and metabolism of orally administered testosterone undecanoate in man.
September 1976, Klinische Wochenschrift,
M E Morris, and G Levy
The absorption of orally administered (12 - 3 H)digoxin in man.
October 1972, Clinical science,
M E Morris, and G Levy
[Absorption of orally administered bromelin].
January 1969, Klinische Wochenschrift,
M E Morris, and G Levy
Absorption of Orally Administered Hyaluronan.
December 2016, Journal of medicinal food,
M E Morris, and G Levy
[Absorption of drugs administered orally].
January 1953, Il Farmaco; edizione scientifica,
M E Morris, and G Levy
The Absorption of Orally Administered Penicillin.
March 1946, Science (New York, N.Y.),
M E Morris, and G Levy
The absorption of orally administered penicillin.
March 1946, Science (New York, N.Y.),
M E Morris, and G Levy
[Evaluation of the intestinal absorption of iron orally administered as chondroitin sulfate in normal subjects].
May 1989, Minerva medica,
Copied contents to your clipboard!