We investigated the role of Staphylococcus saprophyticus in urinary tract infections in men. Of 9,314 urine specimens cultured from men in a veterans hospital only 3 (2 patients) yielded Staphylococcus saprophyticus. Thus, Staphylococcus saprophyticus rarely causes infection in older men and should not be sought routinely by microbiology laboratories in hospitals serving men primarily.