Cell cycle kinetic data can be simulated by a simple chemical kinetic model. 1983

A W Boyd

This paper develops a model of the cell cycle from the assumption that the rate of progression from one mitosis to the next is limited by the time taken to complete a defined sequence of rate-limiting chemical reactions. The model is shown to be related to earlier models which represent limiting forms of this more rigorous description. Earlier models were classified as stochastic or deterministic, but in this case, while the overall structure is deterministic, the individual steps are stochastically variable. Thus, this description demonstrates that both views were partially correct but were incomplete in detail. By applying the model to several experimental cell cycle curves, sets of coefficients corresponding to reaction rate constants could be obtained. A striking feature of these results is that only a small number (1-3) of slow steps dominated the rate of cell division. A discussion of some recent experimental results suggests possible candidates for the few slow rate-limiting steps, and outlines a rigorous method of testing the model.

UI MeSH Term Description Entries
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008938 Mitosis A type of CELL NUCLEUS division by means of which the two daughter nuclei normally receive identical complements of the number of CHROMOSOMES of the somatic cells of the species. M Phase, Mitotic,Mitotic M Phase,M Phases, Mitotic,Mitoses,Mitotic M Phases,Phase, Mitotic M,Phases, Mitotic M
D008954 Models, Biological Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment. Biological Model,Biological Models,Model, Biological,Models, Biologic,Biologic Model,Biologic Models,Model, Biologic
D010781 Photography Method of making images on a sensitized surface by exposure to light or other radiant energy. Photographies
D002453 Cell Cycle The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE. Cell Division Cycle,Cell Cycles,Cell Division Cycles,Cycle, Cell,Cycle, Cell Division,Cycles, Cell,Cycles, Cell Division,Division Cycle, Cell,Division Cycles, Cell
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014747 Vinblastine Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.) Vincaleukoblastine,Cellblastin,Lemblastine,Velban,Velbe,Vinblastin Hexal,Vinblastina Lilly,Vinblastine Sulfate,Vinblastinsulfat-Gry,Sulfate, Vinblastine

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