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N-Methyl-N-amylnitrosamine was given to male Wistar rats in the drinking water at a concentration of 0.003% for 8 weeks. Three rats were autopsied weekly from the first to the 25th week. The stages of hyperplasia, dysplasia and squamous cell carcinoma in the esophagus were chronologically observed. Hyperplasia and dysplasia were found by the 6th week and continuously observed until the end of the experiment. Early squamous cell carcinomas were found in the 13th week. They showed endophytic or exophytic growths. Histologically, the endophytic growths were well-differentiated squamous cell carcinomas and the exophytic growths were poorly-differentiated. Advanced carcinomas were first found in the 15th week and were almost well-differentiated. Carcinomas were not found in papillomas. The incidence of carcinomas increased with time, being 9 out of 15 rats (60%) in the final 21st through 25th weeks. Lymph node metastasis was found in one rat, killed at the 24th week.
K Sasajima, and
Y Taniguchi, and
S Okazaki, and
K Morino, and
K Takubo, and
K Yamashita, and
A Shirota
October 1981,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
K Sasajima, and
Y Taniguchi, and
S Okazaki, and
K Morino, and
K Takubo, and
K Yamashita, and
A Shirota
May 1985,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
K Sasajima, and
Y Taniguchi, and
S Okazaki, and
K Morino, and
K Takubo, and
K Yamashita, and
A Shirota
April 1988,
European journal of cancer & clinical oncology,
K Sasajima, and
Y Taniguchi, and
S Okazaki, and
K Morino, and
K Takubo, and
K Yamashita, and
A Shirota
January 1988,
Digestive diseases and sciences,
K Sasajima, and
Y Taniguchi, and
S Okazaki, and
K Morino, and
K Takubo, and
K Yamashita, and
A Shirota
December 1980,
Zhonghua zhong liu za zhi [Chinese journal of oncology],
K Sasajima, and
Y Taniguchi, and
S Okazaki, and
K Morino, and
K Takubo, and
K Yamashita, and
A Shirota
September 1978,
Cancer,
K Sasajima, and
Y Taniguchi, and
S Okazaki, and
K Morino, and
K Takubo, and
K Yamashita, and
A Shirota
June 1985,
Journal of the National Cancer Institute,
K Sasajima, and
Y Taniguchi, and
S Okazaki, and
K Morino, and
K Takubo, and
K Yamashita, and
A Shirota
July 1986,
Nihon Gan Chiryo Gakkai shi,
K Sasajima, and
Y Taniguchi, and
S Okazaki, and
K Morino, and
K Takubo, and
K Yamashita, and
A Shirota
February 1985,
Cancer research,
K Sasajima, and
Y Taniguchi, and
S Okazaki, and
K Morino, and
K Takubo, and
K Yamashita, and
A Shirota
February 1980,
Gan,
