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Five patients with subacute myelo-optico-neuropathy (SMON) were studied by short-latency somatosensory evoked potentials (SEPs) in response to electrical stimulation of the median nerve and the posterior tibial nerve. SEPs with median nerve stimulation were normal in all cases, but SEPs with posterior tibial nerve stimulation were abnormal in two patients with severe sensory loss in the legs. Abnormalities suggested normal peripheral conduction but a marked attenuation of the cortical component and delayed central conduction. These findings were in conformity with postmortem morphometric analysis, which showed marked reduction of myelinated fibers in the gracile fascicle but only slight reduction of large myelinated fibers in the sural nerve. The pathophysiology of SMON appears to be mainly a central distal axonopathy.
H Shibasaki, and
R Kakigi, and
A Ohnishi, and
Y Kuroiwa
June 1982,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
H Shibasaki, and
R Kakigi, and
A Ohnishi, and
Y Kuroiwa
July 1972,
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H Shibasaki, and
R Kakigi, and
A Ohnishi, and
Y Kuroiwa
April 1980,
Der Nervenarzt,
H Shibasaki, and
R Kakigi, and
A Ohnishi, and
Y Kuroiwa
November 1973,
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H Shibasaki, and
R Kakigi, and
A Ohnishi, and
Y Kuroiwa
October 1969,
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H Shibasaki, and
R Kakigi, and
A Ohnishi, and
Y Kuroiwa
May 1970,
[Hokenfu zasshi] The Japanese journal for public health nurse,
H Shibasaki, and
R Kakigi, and
A Ohnishi, and
Y Kuroiwa
November 1969,
[Hokenfu zasshi] The Japanese journal for public health nurse,
H Shibasaki, and
R Kakigi, and
A Ohnishi, and
Y Kuroiwa
March 1971,
Naika. Internal medicine,
H Shibasaki, and
R Kakigi, and
A Ohnishi, and
Y Kuroiwa
June 1971,
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H Shibasaki, and
R Kakigi, and
A Ohnishi, and
Y Kuroiwa
July 1972,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
