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Sixty-one patients were treated with a three course induction regimen of 5-fluorouracil and cis-platinum for advanced squamous cell carcinoma of the head and neck area. Thirty-three patients (54 percent) had complete clinical remission with the administration of these drugs. Twenty-four patients (39 percent) showed a 50 percent or greater reduction in tumor size, for a significant response rate of 93 percent. The toxicities were within acceptable limits, and only three patients did not complete all three courses. Surgery and radiation therapy were supposed to follow the chemotherapy but several patients refused surgery after the disappearance of their lesion. This has created a problem in patient management.
A Weaver, and
S Flemming, and
J Kish, and
H Vandenberg, and
J Jacob, and
J Crissman, and
M Al-Sarraf
November 1988,
Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
A Weaver, and
S Flemming, and
J Kish, and
H Vandenberg, and
J Jacob, and
J Crissman, and
M Al-Sarraf
January 1982,
Head & neck surgery,
A Weaver, and
S Flemming, and
J Kish, and
H Vandenberg, and
J Jacob, and
J Crissman, and
M Al-Sarraf
February 1988,
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology,
A Weaver, and
S Flemming, and
J Kish, and
H Vandenberg, and
J Jacob, and
J Crissman, and
M Al-Sarraf
November 1986,
British journal of cancer,
A Weaver, and
S Flemming, and
J Kish, and
H Vandenberg, and
J Jacob, and
J Crissman, and
M Al-Sarraf
October 1980,
American journal of surgery,
A Weaver, and
S Flemming, and
J Kish, and
H Vandenberg, and
J Jacob, and
J Crissman, and
M Al-Sarraf
May 2013,
The Israel Medical Association journal : IMAJ,
A Weaver, and
S Flemming, and
J Kish, and
H Vandenberg, and
J Jacob, and
J Crissman, and
M Al-Sarraf
June 1995,
Journal of surgical oncology,
A Weaver, and
S Flemming, and
J Kish, and
H Vandenberg, and
J Jacob, and
J Crissman, and
M Al-Sarraf
February 1989,
European journal of cancer & clinical oncology,
A Weaver, and
S Flemming, and
J Kish, and
H Vandenberg, and
J Jacob, and
J Crissman, and
M Al-Sarraf
October 1990,
International journal of radiation oncology, biology, physics,
A Weaver, and
S Flemming, and
J Kish, and
H Vandenberg, and
J Jacob, and
J Crissman, and
M Al-Sarraf
January 1996,
Neoplasma,
