Cervical spine anomalies in fetal alcohol syndrome. 1982

S J Tredwell, and D F Smith, and P J Macleod, and B J Wood

Fifty cases of well-documented fetal alcohol syndrome were reviewed with the intent of describing the cervical vertebral anomalies. Thirty-eight cases had adequately detailed x-ray examination to be included in this study. Of these, 19 or 53% showed congenital fusion of two or more cervical vertebrae. The associated findings were minor anomalies on the intravenous pyelogram (IVP) in three of 18 IVPs done, mild to moderate microcephaly in 53%, and significant congenital heart anomalies in 41%. Although the vertebral anomalies bear a resemblance to the Klippel Feil syndrome, it is thought that the two syndromes are separate. The patterns of occurrence of the vertebral anomalies are different in the two groups, and the visceral expression of the disorder is also different. The major visceral anomaly in the Klippel Feil syndrome being in the genitourinary system and in the fetal alcohol syndrome being in the cardiovascular system. The patterns, however, are close enough to imply teratogenic event as the etiology in the Klippel Feil group. The occurrence of neck fusion in the fetal alcohol syndrome is common enough for it to be used in making the diagnosis.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007714 Klippel-Feil Syndrome A syndrome characterised by a low hairline and a shortened neck resulting from a reduced number of vertebrae or the fusion of multiple hemivertebrae into one osseous mass. Dystrophia Brevicollis Congenita,Cervical Fusion Syndrome,Klippel-Feil Sequence,Vertebral Cervical Fusion Syndrome,Dystrophia Brevicollis Congenitas,Klippel Feil Syndrome,Syndrome, Klippel-Feil
D008297 Male Males
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011859 Radiography Examination of any part of the body for diagnostic purposes by means of X-RAYS or GAMMA RAYS, recording the image on a sensitized surface (such as photographic film). Radiology, Diagnostic X-Ray,Roentgenography,X-Ray, Diagnostic,Diagnostic X-Ray,Diagnostic X-Ray Radiology,X-Ray Radiology, Diagnostic,Diagnostic X Ray,Diagnostic X Ray Radiology,Diagnostic X-Rays,Radiology, Diagnostic X Ray,X Ray Radiology, Diagnostic,X Ray, Diagnostic,X-Rays, Diagnostic
D002574 Cervical Vertebrae The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK. Cervical Spine,Cervical Spines,Spine, Cervical,Vertebrae, Cervical
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

S J Tredwell, and D F Smith, and P J Macleod, and B J Wood
August 1987, Neuropediatrics,
S J Tredwell, and D F Smith, and P J Macleod, and B J Wood
June 1979, Pediatrics,
S J Tredwell, and D F Smith, and P J Macleod, and B J Wood
November 1977, The Journal of pediatrics,
S J Tredwell, and D F Smith, and P J Macleod, and B J Wood
December 2000, American journal of medical genetics,
S J Tredwell, and D F Smith, and P J Macleod, and B J Wood
August 1992, Archives of ophthalmology (Chicago, Ill. : 1960),
S J Tredwell, and D F Smith, and P J Macleod, and B J Wood
January 1983, Giornale di stomatologia e di ortognatodonzia,
S J Tredwell, and D F Smith, and P J Macleod, and B J Wood
January 1984, Journal of pediatric ophthalmology and strabismus,
S J Tredwell, and D F Smith, and P J Macleod, and B J Wood
February 1997, Pediatrics,
S J Tredwell, and D F Smith, and P J Macleod, and B J Wood
November 1981, American journal of diseases of children (1960),
S J Tredwell, and D F Smith, and P J Macleod, and B J Wood
July 2000, Plastic and reconstructive surgery,
Copied contents to your clipboard!