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Groups of approximately 50 male and 50 female B6C3F1 mice were given butylated hydroxytoluene (BHT) at concentrations of 200, 1000 or 5000 ppm in their diet for 96 wk followed by a basal diet for 8 wk and were then killed. Similar groups of male and female controls were given basal diet throughout the 104 wk. Females given 1000 or 5000 ppm BHT and males given 5000 ppm showed reduced weight gain. Neither survival rates nor food consumption differed between experimental and control groups. No significant changes attributable to BHT treatment were found in the haematological examinations or serum and urine analyses. Tumours were found in many organs, especially the lungs, liver, lymph nodes and spleen, in both the experimental and control groups, but none were related to BHT treatment. Thus this experiment provided no evidence of BHT carcinogenicity in mice.
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