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Twenty-one patients with advanced, inoperable epidermoid carcinoma of the oesophagus were treated with combined 5-fluorouracil (F, 600 mg/m2, days 1 and 8), adriamycin (A, 30 mg/m2, day 1) and cis-platinum (C, 75 mg/m2, day 1), together with hydratation and mannitol-induced diuresis. Each course was repeated after 4 weeks. Response could be assessed in all 21 patients and was objective in seven (33%), who had metastasis prior to treatment. Two of these 7 patients went into complete remission confirmed by negative endoscopy and pathology; 5 showed partial response. Median survival of the 21 patients was 8 months; it fell to 4.5 months in non-responders and rose over 9 months in responders. Three patients survived for more than 16 months. No severe bone marrow depression or nephrotoxicity was observed. The 3-drug combination appeared to be more effective than the additive effects of each drug given separately. It is concluded that the FAP regimen is useful in the treatment of advanced oesophageal tumours.
C Gisselbrecht, and
F Calvo, and
L Mignot, and
E Pujade, and
M Bouvry, and
O Danne, and
D Belpomme, and
F Morvan, and
M Marty
August 1984,
Gan to kagaku ryoho. Cancer & chemotherapy,
C Gisselbrecht, and
F Calvo, and
L Mignot, and
E Pujade, and
M Bouvry, and
O Danne, and
D Belpomme, and
F Morvan, and
M Marty
January 1989,
Actas urologicas espanolas,
C Gisselbrecht, and
F Calvo, and
L Mignot, and
E Pujade, and
M Bouvry, and
O Danne, and
D Belpomme, and
F Morvan, and
M Marty
July 1975,
British journal of diseases of the chest,
C Gisselbrecht, and
F Calvo, and
L Mignot, and
E Pujade, and
M Bouvry, and
O Danne, and
D Belpomme, and
F Morvan, and
M Marty
January 1984,
Acta gastroenterologica Latinoamericana,
C Gisselbrecht, and
F Calvo, and
L Mignot, and
E Pujade, and
M Bouvry, and
O Danne, and
D Belpomme, and
F Morvan, and
M Marty
July 1977,
British journal of diseases of the chest,
C Gisselbrecht, and
F Calvo, and
L Mignot, and
E Pujade, and
M Bouvry, and
O Danne, and
D Belpomme, and
F Morvan, and
M Marty
January 1982,
Head & neck surgery,
C Gisselbrecht, and
F Calvo, and
L Mignot, and
E Pujade, and
M Bouvry, and
O Danne, and
D Belpomme, and
F Morvan, and
M Marty
January 1986,
Oncology,
C Gisselbrecht, and
F Calvo, and
L Mignot, and
E Pujade, and
M Bouvry, and
O Danne, and
D Belpomme, and
F Morvan, and
M Marty
January 1979,
Cancer treatment reports,
C Gisselbrecht, and
F Calvo, and
L Mignot, and
E Pujade, and
M Bouvry, and
O Danne, and
D Belpomme, and
F Morvan, and
M Marty
December 1986,
European journal of cancer & clinical oncology,
C Gisselbrecht, and
F Calvo, and
L Mignot, and
E Pujade, and
M Bouvry, and
O Danne, and
D Belpomme, and
F Morvan, and
M Marty
June 1985,
Gynecologic oncology,
