Biomaterial Database

[Effects of phalloidin in liver cells: binding, morphological changes, and elimination (author's transl)]. 1978

H Schimassek, and D Jeckel

1. The uptake, binding and elimination of phalloidin in liver is compared in adult (180 to 240 g) and "baby" (17 to 19 days old) rats in vivo and in vitro. 2. In both groups there is no relation between the concentration of the poison in the liver and the toxicity. 3. Although baby rats show a significantly higher tolerance against phalloidin than the adult animals, the concentration of the poison in the liver of baby rats is higher, and the elimination is significantly slower than in adult rats. 4. The very tight binding and concentration of phalloidin in the liver is explained by an extremely low dissociation constant. 5. Furthermore, the morphological differences between the poisoning of the liver cells in the entire organ and of isolated liver cells are discussed.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D009842	Oligopeptides	Peptides composed of between two and twelve amino acids.	Oligopeptide
D010590	Phalloidine	Very toxic polypeptide isolated mainly from AMANITA phalloides (Agaricaceae) or death cup; causes fatal liver, kidney and CNS damage in mushroom poisoning; used in the study of liver damage.	Phalloidin
D011485	Protein Binding	The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.	Plasma Protein Binding Capacity,Binding, Protein
D002478	Cells, Cultured	Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.	Cultured Cells,Cell, Cultured,Cultured Cell
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D051381	Rats	The common name for the genus Rattus.	Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus