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We studied the effect of PRL from two species (bovine and turkey) and GH from two species (bovine and turkey) on 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] production by two whole cell preparations from vitamin D-deficient chick kidneys (slices and tubules). We observed that 8 ng/ml turkey PRL stimulated 1,25(OH)2D3 production by renal tubules and slices. Ovine PRL had a similar effect on 1,25(OH)2D3 production but at higher concentrations. In contrast, neither bovine GH nor turkey GH stimulated 1,25(OH)2D3 production appreciably at doses up to 1000 ng/ml. The effect of PRL on 1,25(OH)2D3 production by renal tubules required a 3-h preincubation, although its effect on 1,25(OH)2D3 production by renal slices was immediate. We conclude that PRL, but not GH, directly stimulates 1,25(OH)2D3 production by the chick kidney.
D D Bikle, and
E M Spencer, and
W H Burke, and
C R Rost
February 1988,
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
D D Bikle, and
E M Spencer, and
W H Burke, and
C R Rost
February 1984,
Endocrinology,
D D Bikle, and
E M Spencer, and
W H Burke, and
C R Rost
June 1985,
Acta endocrinologica,
D D Bikle, and
E M Spencer, and
W H Burke, and
C R Rost
February 1975,
The Journal of clinical investigation,
D D Bikle, and
E M Spencer, and
W H Burke, and
C R Rost
March 1974,
Science (New York, N.Y.),
D D Bikle, and
E M Spencer, and
W H Burke, and
C R Rost
September 1983,
The Biochemical journal,
D D Bikle, and
E M Spencer, and
W H Burke, and
C R Rost
January 1999,
Kidney & blood pressure research,
D D Bikle, and
E M Spencer, and
W H Burke, and
C R Rost
March 1985,
Biochemical and biophysical research communications,
D D Bikle, and
E M Spencer, and
W H Burke, and
C R Rost
January 1991,
Developmental biology,
D D Bikle, and
E M Spencer, and
W H Burke, and
C R Rost
October 1979,
Proceedings of the National Academy of Sciences of the United States of America,
