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Tetracyclic triterpenes. Part VI [1]. The synthesis of 4,4,14 alpha-trimethyl-19 (10 leads to 9 beta) abeo-steroids. Synthons for the preparation of cucurbitacins. 1981

Z Paryzek, and R Wydra

The effective synthesis of 4,4,14 alpha-trimethyl-19 (10 leads to 9 beta) abeo-steroids (IV), (V), and (VI) with two- and five-carbon side chains from lanosterol is described. Their structures were proved on the basis of spectral data. The title compounds are the first synthetic synthons for the preparation of 4,4,14 alpha-trimethyl-steroids with an unnatural configuration.

UI MeSH Term Description Entries
D014315 Triterpenes A class of terpenes (the general formula C30H48) formed by the condensation of six isoprene units, equivalent to three terpene units. Triterpene,Triterpenoid,Triterpenoids
D054728 Cucurbitacins Triterpenes that derive from LANOSTEROL by a shift of the C19 methyl to the C9 position. They are found in seeds and roots of CUCURBITACEAE and other plants and are noted for intense bitterness. Cucurbitacin

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