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We have compared the actions of ADM and mAMSA in Chinese hamster V79 cells in vitro, using cell survival and sister-chromatid exchange as end-points. Equimolar concentrations of ADM and mAMSA show similar toxicities to exponentially growing cells, and both drugs are less effective in killing chronically hypoxic and plateau-phase cells. Cytotoxicity to thermotolerant cells (41 degrees C for 16 h previously) shows little difference from that for exponential cells. Pre-treating cells with misonidazole under hypoxic conditions reduces the toxicity of both ADM and mAMSA. In addition, an ADM-resistant Chinese hamster cell line, 77A-177, was cross-resistant to mAMSA. Finally, low equimolar sub-toxic doses of both drugs were found to cause similar increases in the levels of sister-chromatid exchanges in V79 cells. These results reveal no major difference in activity between ADM and mAMSA in vitro.
C West, and
I J Stratford, and
N Barrass, and
E Smith
January 1988,
Cancer chemotherapy and pharmacology,
C West, and
I J Stratford, and
N Barrass, and
E Smith
November 1982,
Mutation research,
C West, and
I J Stratford, and
N Barrass, and
E Smith
January 1984,
Basic life sciences,
C West, and
I J Stratford, and
N Barrass, and
E Smith
July 1976,
Cancer research,
C West, and
I J Stratford, and
N Barrass, and
E Smith
January 1987,
Oncology,
C West, and
I J Stratford, and
N Barrass, and
E Smith
December 2002,
Journal of molecular and cellular cardiology,
C West, and
I J Stratford, and
N Barrass, and
E Smith
October 1980,
Cancer research,
C West, and
I J Stratford, and
N Barrass, and
E Smith
December 1979,
Biochemical and biophysical research communications,
C West, and
I J Stratford, and
N Barrass, and
E Smith
February 1982,
Chemico-biological interactions,
C West, and
I J Stratford, and
N Barrass, and
E Smith
February 1961,
Genetics,
